E-ISSN 2277-338X | ISSN 2320-4664
 

Review Article 


The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved

Paphapin Pairojtanachai.

Abstract
Cystic fibrosis is a disease found predominantly in Caucasians. It is caused by an autosomal recessive mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The mutation(s) lead to defective CFTR proteins, or transmembrane cyclic adenosine monophosphate (cAMP)-dependent chloride channels found on the surface of epithelial cells. The respiratory system is most impacted by this abnormal phenotype, and lung disease can bring about the majority of the various issues that a cystic fibrosis patient has to deal with. Even so, due to the excess amount of mucus that is secreted, individuals diagnosed with cystic fibrosis experience complications in other organs as well. Today, newborn screening is widely used as a means of early diagnosis of cystic fibrosis, and there are also multiple other novel technologies that aim for accurate diagnosis and prevention of the disease. In addition, while traditional treatment programs are based on curing the symptoms that the patients exhibit, new regimens are directed at correcting the error that occurred at the molecular level. With improvements made in the medical field, cystic fibrosis patients are able to live longer and have a better quality of life. This review article serves as a compilation of the current knowledge on the causes of cystic fibrosis, the physiological processes associated with the disease, the techniques for diagnosis of the disease, and finally the recent and upcoming therapeutics for the disease.

Key words: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cystic Fibrosis Pathology; Cystic Fibrosis Diagnosis; Cystic Fibrosis Treatment


 
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Pubmed Style

Paphapin Pairojtanachai. The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. Int J Med Sci Public Health. 2020; 9(8): 452-458. doi:10.5455/ijmsph.2020.08132202024082020


Web Style

Paphapin Pairojtanachai. The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. http://www.ijmsph.com/?mno=124580 [Access: September 28, 2020]. doi:10.5455/ijmsph.2020.08132202024082020


AMA (American Medical Association) Style

Paphapin Pairojtanachai. The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. Int J Med Sci Public Health. 2020; 9(8): 452-458. doi:10.5455/ijmsph.2020.08132202024082020



Vancouver/ICMJE Style

Paphapin Pairojtanachai. The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. Int J Med Sci Public Health. (2020), [cited September 28, 2020]; 9(8): 452-458. doi:10.5455/ijmsph.2020.08132202024082020



Harvard Style

Paphapin Pairojtanachai (2020) The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. Int J Med Sci Public Health, 9 (8), 452-458. doi:10.5455/ijmsph.2020.08132202024082020



Turabian Style

Paphapin Pairojtanachai. 2020. The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. International Journal of Medical Science and Public Health, 9 (8), 452-458. doi:10.5455/ijmsph.2020.08132202024082020



Chicago Style

Paphapin Pairojtanachai. "The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved." International Journal of Medical Science and Public Health 9 (2020), 452-458. doi:10.5455/ijmsph.2020.08132202024082020



MLA (The Modern Language Association) Style

Paphapin Pairojtanachai. "The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved." International Journal of Medical Science and Public Health 9.8 (2020), 452-458. Print. doi:10.5455/ijmsph.2020.08132202024082020



APA (American Psychological Association) Style

Paphapin Pairojtanachai (2020) The pathological features of cystic fibrosis and the diagnostic techniques and treatments involved. International Journal of Medical Science and Public Health, 9 (8), 452-458. doi:10.5455/ijmsph.2020.08132202024082020





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