E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients

Sudha Jha, Shailaza Shrestha, Hundal Parchwani, Rahul Rai.

Abstract
Background: Hypertension is a hallmark risk factor for coronary heart disease, cerebrovascular stroke, congestive heart failure, cardiac arrhythmia, cardiomyopahy and abnormal renal function. Free radicals are involved in the pathogenesis of hypertension by altering endothelial function via oxidative stress.

Aims & Objective: To assess the level of antioxidant enzymes superoxide dismutase (SOD), Catalase, Glutathione peroxidase (GPX) and lipid peroxidation product malondialdehyde (MDA) in hypertensive patients.

Materials and Methods: 100 hypertensive patients and 25 healthy controls were included. Serum levels of enzymes and MDA were estimated by spectrophotometric methods.

Results: The level of antioxidant enzymes were significantly lower and MDA was significantly higher in hypertensive patients as compared to controls (p<0.05). For SOD, significant difference could not be obtained between controls and stage I hypertensives with drugs (p>0.05). We also compared the enzymes and MDA level within the hypertensive groups. Significant results were obtained (p<0.05, 0.01). On comparison between stage I and stage II hypertensive without and with drugs, we found that hypertensive patients on drug have significantly higher level of antioxidant enzymes and lower level of MDA than those without anti-hypertensive drugs (p<0.01).

Conclusion: Our study shows that hypertension is associated with oxidative stress. Adequate control of blood pressure and antihypertensive therapy decrease the oxidative stress, improves antioxidant status and endothelial function.

Key words: Oxidative stress, Malondialdehyde(MDA), glutathione peroxidase(GPX), Superoxide dismutase(SOD), Catalase


 
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How to Cite this Article
Pubmed Style

Jha S, Shrestha S, Parchwani H, Rai R. Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. Int J Med Sci Public Health. 2014; 3(9): 1074-1078. doi:10.5455/ijmsph.2014.180620143


Web Style

Jha S, Shrestha S, Parchwani H, Rai R. Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. http://www.ijmsph.com/?mno=160741 [Access: April 22, 2018]. doi:10.5455/ijmsph.2014.180620143


AMA (American Medical Association) Style

Jha S, Shrestha S, Parchwani H, Rai R. Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. Int J Med Sci Public Health. 2014; 3(9): 1074-1078. doi:10.5455/ijmsph.2014.180620143



Vancouver/ICMJE Style

Jha S, Shrestha S, Parchwani H, Rai R. Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. Int J Med Sci Public Health. (2014), [cited April 22, 2018]; 3(9): 1074-1078. doi:10.5455/ijmsph.2014.180620143



Harvard Style

Jha, S., Shrestha, S., Parchwani, H. & Rai, R. (2014) Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. Int J Med Sci Public Health, 3 (9), 1074-1078. doi:10.5455/ijmsph.2014.180620143



Turabian Style

Jha, Sudha, Shailaza Shrestha, Hundal Parchwani, and Rahul Rai. 2014. Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. International Journal of Medical Science and Public Health, 3 (9), 1074-1078. doi:10.5455/ijmsph.2014.180620143



Chicago Style

Jha, Sudha, Shailaza Shrestha, Hundal Parchwani, and Rahul Rai. "Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients." International Journal of Medical Science and Public Health 3 (2014), 1074-1078. doi:10.5455/ijmsph.2014.180620143



MLA (The Modern Language Association) Style

Jha, Sudha, Shailaza Shrestha, Hundal Parchwani, and Rahul Rai. "Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients." International Journal of Medical Science and Public Health 3.9 (2014), 1074-1078. Print. doi:10.5455/ijmsph.2014.180620143



APA (American Psychological Association) Style

Jha, S., Shrestha, S., Parchwani, H. & Rai, R. (2014) Study on the levels of oxidant and anti-oxidant enzymes in hypertensive patients. International Journal of Medical Science and Public Health, 3 (9), 1074-1078. doi:10.5455/ijmsph.2014.180620143





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