E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations

Dharmendra Tiwari, O P Jatav, Manish Dudani.

Cited by (2)

Abstract
Background: High suicide rate is reported in India, and poisoning seems to be main cause in majority of these suicide cases. An enhanced rate is seen in poisoning by hair dye, and in few places, it comprises a huge part of the poisoning cases.

Objective: To study the clinical profile, electrocardiographic (ECG) changes, and biochemical parameters of patients presenting with hair dye poisoning.

Material and Methods: A prospective study of 50 indoor patients admitted to poison ward of Department of Medicine, GR Medical College and JA Group of Hospitals, Gwalior, Madhya Pradesh, India, was done from August 1, 2008, to October 30, 2009. The parameters studied in all the patients were cause of ingestion, compound involved, time elapse between ingestion and admission to the hospital, duration of hospital stay, need for assisted ventilation, and cardiac manifestations at the time of presentation and during hospital stay. Routine investigations such as renal function, liver function tests, creatinine phosphokinase (CPK) levels, and cardiac marker test (CPK-MB) were done. ECG was done for all the patients daily to observe rate, rhythm, ST/T abnormalities, conduction defects, and P-R and Q-T intervals disturbances.

Result: Of 50 patients included in the study, 38 (76%) patients were between the age group of 1525 years, and there was a female predominance (60%); 55% of male population was from the rural area, and 93.33% female belonged to urban area. Twenty-eight (56%) patients reached hospital within 6 h of hair dye ingestion. Angioneurotic edema was the most common clinical finding. Renal functions were deranged in 38% and liver functions in 18% and CPK-MB was raised in 82% patients. ECG changes were observed in 90% patients of which ST/T changes were most common. Ten (20%) patients died in this study.

Conclusion: The hair dye poisoning is not so uncommon and is associated with effects on vital organs resulting in derangements of renal, hepatic and cardiac functions. Angioneurotic edema and myocarditis can be fatal. ECG changes and elevated CPK-MB are found in majority of the patients.

Key words: Hair dye, paraphenylene-diamine, PPD, myocarditis, angioneurotic edema


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Dharmendra Tiwari
Articles by O P Jatav
Articles by Manish Dudani
on Google
on Google Scholar


REFERENCES
1. Jain PK, SharmaAK,Agarwal N, Sengar NS,Agarwal N, Siddiqui MZ, et al. A prospective clinical study of myocarditis in cases of acute ingestion of paraphenylene diamine (hair dye) poisoning in northern India. J Assoc Physicians India 2013;61:633-6, 644. [Pubmed]   
2. Sakuntala P, Khan PM, Sudarsi B, Manohar S, Siddeswari R, Swaroop K. Clinical profile and complications of hair dye poisoning. Int J Sci Res Publ 2015;5(6):1-4.
3. World Health Organization. 2008. World Suicide Prevention Day. Available http://www.who.int/mental_health/prevention/suicide/wspd_2008_statement.pdf (last accessed on August 23, 2015).
4. Jain PK, Sharma AK, Agarwal N, Sengar NS, Siddiqui MZ, Kumar SA, et al. A prospective clinical study of myocarditis in cases of paraphenylenediamine (hair dye) poisoning in northern India. J Toxicol Environ Health A 2012;4(7):106-16.
5. Balasubramanian D, Subramanian S, Shanmugam K. Clinical profile and mortality determinants in hair dye poisoning. Ann Nigerian Med 2014;8(2):82-6. [DOI via Crossref]   
6. Varadhraj PG, Sasikala M, Cheemalkonda R, Banarjee R, Padaki NR, Reddy N. Hairdye-induced hepatitis: an unusal cause of acute hepatitis. Saudi J Gastroenterol 2009;15(2):138-9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
7. Suganthakumar MN, Ganesh R. Hair dye—an emerging suicidal agent: our experience. Otolaryngol Online J 2012;2:1-11.
8. Patel V, Ramasundarahettige C, Vijayakumar L, Thakur JS, Gajalakshmi V, Gururaj G, et al. Suicide mortality in India: a nationally representative survey. Lancet 2012;379:2343-51. [DOI via Crossref]   
9. Hasim S, Hamza Y, Yahia B, Khogali F, Sulieman G. Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum. Ann Trop Pediatr 1984;12:3-6. [DOI via Crossref]   

This Article Cited By the following articles

A systematic review and meta-analysis of the prevalence and complications of paraphenylenediamine-containing hair dye poisoning in developing countries
Indian J Pharmacol 2019; 51(5): 302.

1
 
Toxicological studies on commercial hair dye brand commonly used in Saudi Arabia: histological study of the liver, kidney, heart, and testis
JoBAZ 2018; 79(1): .

2
 
How to Cite this Article
Pubmed Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. Int J Med Sci Public Health. 2016; 5(7): 1313-1316. doi:10.5455/ijmsph.2016.25082015194


Web Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. http://www.ijmsph.com/?mno=200030 [Access: September 27, 2020]. doi:10.5455/ijmsph.2016.25082015194


AMA (American Medical Association) Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. Int J Med Sci Public Health. 2016; 5(7): 1313-1316. doi:10.5455/ijmsph.2016.25082015194



Vancouver/ICMJE Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. Int J Med Sci Public Health. (2016), [cited September 27, 2020]; 5(7): 1313-1316. doi:10.5455/ijmsph.2016.25082015194



Harvard Style

Dharmendra Tiwari, O P Jatav, Manish Dudani (2016) Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. Int J Med Sci Public Health, 5 (7), 1313-1316. doi:10.5455/ijmsph.2016.25082015194



Turabian Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. 2016. Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. International Journal of Medical Science and Public Health, 5 (7), 1313-1316. doi:10.5455/ijmsph.2016.25082015194



Chicago Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. "Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations." International Journal of Medical Science and Public Health 5 (2016), 1313-1316. doi:10.5455/ijmsph.2016.25082015194



MLA (The Modern Language Association) Style

Dharmendra Tiwari, O P Jatav, Manish Dudani. "Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations." International Journal of Medical Science and Public Health 5.7 (2016), 1313-1316. Print. doi:10.5455/ijmsph.2016.25082015194



APA (American Psychological Association) Style

Dharmendra Tiwari, O P Jatav, Manish Dudani (2016) Prospective study of clinical profile in hair dye poisoning (PPD) with special reference to electrocardiographic manifestations. International Journal of Medical Science and Public Health, 5 (7), 1313-1316. doi:10.5455/ijmsph.2016.25082015194





Most Viewed Articles
  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Most Downloaded
  • Minor disorder of pregnancy and its home management
    Lata Gururani, Atul Kumar, Gomathi Mahalingam
    Int J Med Sci Public Health. 2016; 5(4): 684-687
    » Abstract & References » doi: 10.5455/ijmsph.2016.03082015111

  • Association between serum ferritin and thyroid hormone profile in hypothyroidism
    Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair
    Int J Med Sci Public Health. 2015; 4(6): 863-865
    » Abstract & References » doi: 10.5455/ijmsph.2015.24012015174

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Effect of sleep deprivation on the attitude and performance of medical students, Riyadh, Saudi Arabia
    Hussein Saad Amin, Ibrahim Salamah Almazroua, Abdullah Sulaiman Alsahlan, Mohammed Abdullah Alrishan, Houssam Mourad Elmourad, Mohammed Mansour Alotaibi, Abdulaziz Ibrahim Almohaisin
    Int J Med Sci Public Health. 2016; 5(3): 575-580
    » Abstract & References » doi: 10.5455/ijmsph.2016.17112015207

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 34 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 16 times [Click to see citing articles]

  • Design of fuzzy expert system for diagnosis of cardiac diseases
    Smita Sushil Sikchi , Sushil Sikchi , M S ALI
    Int J Med Sci Public Health. 2013; 2(1): 56-61
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.56-61
    Cited : 11 times [Click to see citing articles]

  • Sugammadex associate persistant bradycardia
    Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu
    Int J Med Sci Public Health. 2014; 3(3): 372-374
    » Abstract & References » doi: 10.5455/ijmsph.2013.251220131
    Cited : 11 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 10 times [Click to see citing articles]