E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD)

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella.

Abstract
Background: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and mortality. Several studies showed evidence that there is a strong association between oxidative stress and COPD. Decrease in antioxidants also contributes to oxidative stress, because antioxidants not only protect against the direct injurious effects of oxidants, but also alter the inflammatory events that play an important role in the pathogenesis of COPD.

Objective: To evaluate the erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) as a biomarker of lipid peroxidation in patients with COPD and in controls.

Materials and Methods: A total number of 120 subjects were studied, comprising 60 healthy controls and 60 COPD cases. Among 60 COPD cases, 30 were patients with chronic bronchitis and 30 were patients with emphysema. Erythrocyte GSH was estimated by Ernest Beutler et al method, serum SOD activity by Marklund and Marklund method, and MDA by Kei Satoh method.

Result: The levels of erythrocyte GSH and SOD activity were significantly decreased in COPD cases when compared with controls. They were significantly decreased in patients with emphysema when compared to controls and were significantly increased in patients with emphysema when compared with patients with chronic bronchitis.

Conclusion: This study suggests the increased MDA levels in patients with COPD because of increased lipid peroxidation mediated by toxic free radicals such as superoxide ion, hydrogen peroxide, and hydroxyl radical. The decrease in antioxidant levels of erythrocyte GSH and SOD activity among patients with COPD appear to be mainly a consequence of increased oxidative stress.

Key words: COPD, superoxide dismutase, malondialdehyde, antioxidants, erythrocyte reduced glutathione


 
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How to Cite this Article
Pubmed Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). Int J Med Sci Public Health. 2016; 5(7): 1374-1379. doi:10.5455/ijmsph.2016.12102015216


Web Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). http://www.ijmsph.com/?mno=205293 [Access: September 27, 2020]. doi:10.5455/ijmsph.2016.12102015216


AMA (American Medical Association) Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). Int J Med Sci Public Health. 2016; 5(7): 1374-1379. doi:10.5455/ijmsph.2016.12102015216



Vancouver/ICMJE Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). Int J Med Sci Public Health. (2016), [cited September 27, 2020]; 5(7): 1374-1379. doi:10.5455/ijmsph.2016.12102015216



Harvard Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella (2016) Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). Int J Med Sci Public Health, 5 (7), 1374-1379. doi:10.5455/ijmsph.2016.12102015216



Turabian Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. 2016. Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). International Journal of Medical Science and Public Health, 5 (7), 1374-1379. doi:10.5455/ijmsph.2016.12102015216



Chicago Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. "Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD)." International Journal of Medical Science and Public Health 5 (2016), 1374-1379. doi:10.5455/ijmsph.2016.12102015216



MLA (The Modern Language Association) Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella. "Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD)." International Journal of Medical Science and Public Health 5.7 (2016), 1374-1379. Print. doi:10.5455/ijmsph.2016.12102015216



APA (American Psychological Association) Style

Karuna sree Yerrajwala, Vijaya saradhini, Suneetha Gudimella (2016) Evaluation of antioxidants in patients with chronic obstructive pulmonary disease (COPD). International Journal of Medical Science and Public Health, 5 (7), 1374-1379. doi:10.5455/ijmsph.2016.12102015216





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