E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel.

Cited by (1)

Abstract
Background: In this era of polypharmacy in chronic disease such as hypertension and diabetes, there are more chances of food-drug interactions. Significant food-drug interaction can cause failure of drug therapy or serious adverse effect to patient.

Objective: To assess the potential food-drug interaction (pFDI) patients attending Medicine outpatient department (OPD) at a tertiary-care teaching hospital in Valsad, Gujarat, India.

Materials and Methods: The prescriptions of patients attending Medicine OPD were analyzed for demography of patients and pFDI. Freely available Drug Interaction Checker on Internet was used to analyze pFDI. Interactions were classified major, moderate, and minor according to severity and by their mechanism as pharmacokinetic or pharmacodynamic types. Statistical analysis was done using appropriate Microsoft Excel.

Result: A total of 300 prescriptions were collected from study site; from those, 253 prescriptions were included in our study. From these, 128 (50.59%) were from male patients and 125 (49.41%) from female patients. The number of drugs prescribed to the individual patient was 4.4 ± 1.48 (range, 2–12). The frequency of pFDI per patient was 0.97 ± 1.03 (range, 0–5). The number of pFDI increased with increase in the age of patients and the number of drugs prescribed. Among 253 patients, 149 (59%) patients showed at least one pFDI, and 104 (41%) patients did not show pFDI. Among 243 pFDIs, 26 (10.69%) were pharmacodynamic and 217 (89.30%) pharmacokinetic types. In this study, four (1.65%) interactions were major, while those with moderate and minor severities accounted for 173 (71.19%) and 66 (27.16%), respectively.

Conclusion: In this study, it was found that most of pFDIs were pharmacokinetic in nature and of moderate severity. Physician should be aware of significant food-drug interaction with food consumed by local community.

Key words: Potential food-drug interaction (pFDI), pharmacokinetic food-drug interaction, pharmacodynamic food-drug interaction, grapefruit juice


 
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This Article Cited By the following articles


2018; (): 337.

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How to Cite this Article
Pubmed Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. Int J Med Sci Public Health. 2016; 5(7): 1465-1470. doi:10.5455/ijmsph.2016.28102015237


Web Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. http://www.ijmsph.com/?mno=206390 [Access: September 29, 2020]. doi:10.5455/ijmsph.2016.28102015237


AMA (American Medical Association) Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. Int J Med Sci Public Health. 2016; 5(7): 1465-1470. doi:10.5455/ijmsph.2016.28102015237



Vancouver/ICMJE Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. Int J Med Sci Public Health. (2016), [cited September 29, 2020]; 5(7): 1465-1470. doi:10.5455/ijmsph.2016.28102015237



Harvard Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel (2016) Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. Int J Med Sci Public Health, 5 (7), 1465-1470. doi:10.5455/ijmsph.2016.28102015237



Turabian Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. 2016. Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. International Journal of Medical Science and Public Health, 5 (7), 1465-1470. doi:10.5455/ijmsph.2016.28102015237



Chicago Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. "Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD." International Journal of Medical Science and Public Health 5 (2016), 1465-1470. doi:10.5455/ijmsph.2016.28102015237



MLA (The Modern Language Association) Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel. "Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD." International Journal of Medical Science and Public Health 5.7 (2016), 1465-1470. Print. doi:10.5455/ijmsph.2016.28102015237



APA (American Psychological Association) Style

Nilesh Chavda, Jatin V Dhanani, Priti Solanky, Kirtida Tandel, Nirav Patel (2016) Are all types of food safe with prescribed medicines? A study of potential food-drug interactions in patients attending Medicine OPD. International Journal of Medical Science and Public Health, 5 (7), 1465-1470. doi:10.5455/ijmsph.2016.28102015237





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