E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus

Kapil Kumar Garg, S N Chugh.

Abstract
Background: There is a need for new oral antidiabetic agents with different modes of action. Moving away from conventional “Triumvirate,” most important player implicated in the pathogenesis of type 2 diabetes is the brain, which along with seven other companions form the “ominous octet.” Bromocriptine mesylate is one such drug which acts on brain, upregulating dopaminergic tone thereby reducing insulin resistance and improving glucose tolerance.

Objectives: To study the efficacy of bromocriptine mesylate as an add-on therapy in patients with T2DM inadequately controlled on two oral antidiabetic drugs.

Materials and Methods: A total of 50 patients according to inclusion and exclusion criteria formed the subject matter of this prospective, non-randomized study. Bromocriptine mesylate was added in weekly 0.8 mg increments to achieve a target dose between 1.6 and 4.8 mg depending on the patient tolerance. Baseline measurements of fasting blood sugar (FBS), postprandial blood sugar (PPBS), and glycosylated hemoglobin (HbA1c) were followed up at 6 and 12 weeks. Appropriate history, examination and laboratory tests were done at each visit to identify any adverse effects. Paired Student’s t-test was used for analysis using SPSS 17 statistical software.

Results: Baseline mean FBS, PPBS, and HbA1c values were 146.86 mg/dL, 227.92 mg/dL, and 8.66%, respectively. After 6 weeks of bromocriptine mesylate add-on therapy, FBS, PPBS and HbA1c showed a mean fall of 19.96 mg/dL, 45.90 mg/dL, and 0.85%, respectively, which was found to be statistically significant (P < 0.05). After 12 weeks of therapy, FBS, PPBS, and HbA1c showed a mean fall of 34.24 mg/dL, 60.36 mg/dL, and 1.56%, respectively, when compared with baseline values, was found to be statistically significant (P < 0.05).

Conclusion: Patients showed a significant reduction in fasting, PPBS and HbA1c levels both at 6 and 12 weeks without any significant adverse effects. Reduction in HbA1c was more in diabetics with poor baseline glycemic control compared to those having fair and good control. Bromocriptine mesylate is an effective antidiabetic drug which when added on to existing oral antidiabetic therapy in uncontrolled diabetes helps achieve optimal glycemic control.

Key words: Diabetes Mellitus; Glycosylated Hemoglobin A; Insulin Resistance; Dopamine Agonists; Bromocriptine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Kapil Kumar Garg
Articles by S N Chugh
on Google
on Google Scholar
Article Statistics
 Viewed: 853
Downloaded: 138
Cited: 0

How to Cite this Article
Pubmed Style

Garg KK, Chugh SN. Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. Int J Med Sci Public Health. 2017; 6(6): 992-995. doi:10.5455/ijmsph.2017.1268827012017


Web Style

Garg KK, Chugh SN. Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. http://www.ijmsph.com/?mno=252991 [Access: April 22, 2018]. doi:10.5455/ijmsph.2017.1268827012017


AMA (American Medical Association) Style

Garg KK, Chugh SN. Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. Int J Med Sci Public Health. 2017; 6(6): 992-995. doi:10.5455/ijmsph.2017.1268827012017



Vancouver/ICMJE Style

Garg KK, Chugh SN. Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. Int J Med Sci Public Health. (2017), [cited April 22, 2018]; 6(6): 992-995. doi:10.5455/ijmsph.2017.1268827012017



Harvard Style

Garg, K. K. & Chugh, S. N. (2017) Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. Int J Med Sci Public Health, 6 (6), 992-995. doi:10.5455/ijmsph.2017.1268827012017



Turabian Style

Garg, Kapil Kumar, and S N Chugh. 2017. Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. International Journal of Medical Science and Public Health, 6 (6), 992-995. doi:10.5455/ijmsph.2017.1268827012017



Chicago Style

Garg, Kapil Kumar, and S N Chugh. "Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus." International Journal of Medical Science and Public Health 6 (2017), 992-995. doi:10.5455/ijmsph.2017.1268827012017



MLA (The Modern Language Association) Style

Garg, Kapil Kumar, and S N Chugh. "Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus." International Journal of Medical Science and Public Health 6.6 (2017), 992-995. Print. doi:10.5455/ijmsph.2017.1268827012017



APA (American Psychological Association) Style

Garg, K. K. & Chugh, S. N. (2017) Efficacy of bromocriptine mesylate as add-on oral antidiabetic agent in type 2 diabetes mellitus. International Journal of Medical Science and Public Health, 6 (6), 992-995. doi:10.5455/ijmsph.2017.1268827012017





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Recent update on osteoporosis
    Vijender Agrawal, Dharmendra Gupta
    Int J Med Sci Public Health. 2013; 2(2): 164-168
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.162-166

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Study of psychological stress among undergraduate medical students of government medical college, Surat.
    Priti Solanky, Binita Desai, Abhay Kavishwar, S. L. Kantharia
    Int J Med Sci Public Health. 2012; 1(2): 38-42
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.38-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 21 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 5 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 5 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 5 times [Click to see citing articles]

  • Prevalence and clinical characteristics of autism spectrum disorders in school-age children in Taif- KSA
    Ali H.S Al-Zahrani
    Int J Med Sci Public Health. 2013; 2(3): 578-582
    » Abstract & References » doi: 10.5455/ijmsph.2013.160420133
    Cited : 5 times [Click to see citing articles]

  • Electrocardiographic changes during acute mental stress
    Arpana Bhide, Rajasekhar Durgaprasad, Latheef Kasala, Vanajakshamma Velam, Narendra Hulikal
    Int J Med Sci Public Health. 2016; 5(5): 835-838
    » Abstract & References » doi: 10.5455/ijmsph.2016.19082015137
    Cited : 5 times [Click to see citing articles]

  • Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India
    Vuddandi Prabodh, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, Ravi Shekhara
    Int J Med Sci Public Health. 2012; 1(2): 118-120
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.118-120
    Cited : 4 times [Click to see citing articles]

  • Role of HRCT temporal bone in pre operative evaluation of choesteatoma
    Chintan Shah, Pinal Shah, Satish Shah
    Int J Med Sci Public Health. 2014; 3(1): 69-72
    » Abstract & References » doi: 10.5455/ijmsph.2013.031020131
    Cited : 4 times [Click to see citing articles]