E-ISSN 2277-338X | ISSN 2320-4664
 

Review Article 


The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review

Shinjini Chakraborty, Debarpan Guhathakurta, Kumarjeet Banerjee, Anubrata Bhattacharya, Bibaswan Basu, Devashish Sen.

Abstract
The established paradigm of stress axis is not only borne by the hypothalamic-pituitary-adrenal (HPA) axis. There are various “fine-tuners” in the form of neuromodulators whose intricate functioning is under active investigation. Two such neuromodulators, namely nociceptin and orexin are interesting candidates to further evaluate their respective roles and possible cross-talk in due course of stress. In addition, apart from this outlook toward stress, immune stress is also perceived as an impending threat to the physiology and probably implicates the HPA axis in ways that we fail to comprehend with our current crux of knowledge. Sepsis or system inflammatory response syndrome is an exemplary of such an immune stress where the role of the HPA axis has been evidentially supported. An interesting question which arises is how would neurologically perceived stress and sepsis be guided by various neuromodulators. The scope of this review is to evaluate the existing literature where we look at the role of nociceptin and orexin in guiding the complex etiology of stress and sepsis, respectively. Extensive review has suggested, there also might be a hypothetical “cross-talk” between nociceptin and orexin, though this again has to be supported by further investigations.

Key words: Nociceptin; Orexin; Stress; Sepsis


 
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Pubmed Style

Chakraborty S, Guhathakurta D, Banerjee K, Bhattacharya A, Basu B, Sen D. The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. Int J Med Sci Public Health. 2017; 6(6): 980-986. doi:10.5455/ijmsph.2017.1269727122016


Web Style

Chakraborty S, Guhathakurta D, Banerjee K, Bhattacharya A, Basu B, Sen D. The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. http://www.ijmsph.com/?mno=253954 [Access: May 25, 2018]. doi:10.5455/ijmsph.2017.1269727122016


AMA (American Medical Association) Style

Chakraborty S, Guhathakurta D, Banerjee K, Bhattacharya A, Basu B, Sen D. The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. Int J Med Sci Public Health. 2017; 6(6): 980-986. doi:10.5455/ijmsph.2017.1269727122016



Vancouver/ICMJE Style

Chakraborty S, Guhathakurta D, Banerjee K, Bhattacharya A, Basu B, Sen D. The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. Int J Med Sci Public Health. (2017), [cited May 25, 2018]; 6(6): 980-986. doi:10.5455/ijmsph.2017.1269727122016



Harvard Style

Chakraborty, S., Guhathakurta, D., Banerjee, K., Bhattacharya, A., Basu, B. & Sen, D. (2017) The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. Int J Med Sci Public Health, 6 (6), 980-986. doi:10.5455/ijmsph.2017.1269727122016



Turabian Style

Chakraborty, Shinjini, Debarpan Guhathakurta, Kumarjeet Banerjee, Anubrata Bhattacharya, Bibaswan Basu, and Devashish Sen. 2017. The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. International Journal of Medical Science and Public Health, 6 (6), 980-986. doi:10.5455/ijmsph.2017.1269727122016



Chicago Style

Chakraborty, Shinjini, Debarpan Guhathakurta, Kumarjeet Banerjee, Anubrata Bhattacharya, Bibaswan Basu, and Devashish Sen. "The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review." International Journal of Medical Science and Public Health 6 (2017), 980-986. doi:10.5455/ijmsph.2017.1269727122016



MLA (The Modern Language Association) Style

Chakraborty, Shinjini, Debarpan Guhathakurta, Kumarjeet Banerjee, Anubrata Bhattacharya, Bibaswan Basu, and Devashish Sen. "The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review." International Journal of Medical Science and Public Health 6.6 (2017), 980-986. Print. doi:10.5455/ijmsph.2017.1269727122016



APA (American Psychological Association) Style

Chakraborty, S., Guhathakurta, D., Banerjee, K., Bhattacharya, A., Basu, B. & Sen, D. (2017) The role of nociceptin and orexin in the pathophysiology of psychogenic stress and sepsis: A literature review. International Journal of Medical Science and Public Health, 6 (6), 980-986. doi:10.5455/ijmsph.2017.1269727122016





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