E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Toxicological effects of phosphide powder residue in female rats

Ayobola Iyanda.

Cited by (1)

Abstract
Background: Fumigation of cowpea (Vigna unguiculata L. Walp.) using aluminium phosphide is a common practice and contact with this chemical has been demonstrated to result in organ damage, but there is dearth of data on the impact of its powder residue on a mammalian species.

Aims & Objective: The aim of this study is to determine the effect of post-fumigation residue on both liver and kidney of female Wistar rats.

Material and Methods: Eighteen rats were randomly divided into each of the three experimental groups. A group was fed with untreated cowpea and served as control; either of the two other groups was fed phosphide-powder residue contaminated or uncontaminated cowpea. Serum obtained from blood that was collected through retro-orbital bleeding was utilized for biochemical analysis.

Results: While contact with treated but uncontaminated cowpea did not result in either hepatic or renal damage, rats fed phosphide-residue contaminated cowpea exhibited both hepatic and renal damage as the indices (alanine & aspartate aminotransferases, γ- glutamyl transferase, alkaline phosphatase, total protein, albumin, urea, uric acid, creatinine) of study were significantly different (p<0.05) compared with control.

Conclusion: The results of this study suggest that phosphide residue may both nephro and hepatotoxic to female Wistar rats.

Key words: Liver; Kidney; Phosphide Residue; Cowpea


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ayobola Iyanda
on Google
on Google Scholar
Article Statistics
 Viewed: 2567
Downloaded: 688
Cited: 1

REFERENCES
1. Bergmeyer HU, Scheibe P, Wahlefeld AW. Methods for aspartate and alanine amino transferase. Clin Chem. 1979;125: 1487.
2. McComb RB, Bowers GN, Jr. A study of optimum buffer conditions for measuring alkaline phosphatase activity in human serum. Clin Chem. 1972;18:97.
3. Koch TR, Doumas BT. Bilirubin: Total & conjugated, modified Jendrassik- Grof method. Am Ass Clin Chem. 1982;113.
4. Kingsley CR. The direct biuret method for determination of serum proteins. J Lab Clin Med 28: 1982; 1093-1103.
5. Baeeri M, Shariatpanahi M, Baghaei A, Ghasemi-Niri SF, Mohammadi H, Mohammadirad A, et al. On the benefit of magnetic magnesium nanocarrier in cardiovascular toxicity of aluminum phosphide. Toxicol Ind Health. 2013;29(2):126-35. [DOI via Crossref]   
6. Darbari A, Tandon S, Chaudhary S, Bharadwaj M, Kumar A, Singh GP. Esophageal Injuries Due to Aluminum Phosphide Tablet Poisoning in India. Asian Cardiovasc Thorac Ann. 2008;16(4):298-300. [DOI via Crossref]   
7. Kapoor S, Naik S, Kumar R, Sharma S, Pruthi HS, Varshney S. Benign esophageal stricture following aluminum phosphide poisoning. Indian J Gastroenterol. 2005;24:261-2.
8. Talukdar R, Singal DK, Tandon RK. Aluminum phosphide-induced esophageal stricture. Indian J Gastroenterol. 2006;25:98-9.
9. Madan K, Chalamalasetty SB, Sharma M, Makharia G. Corrosive-like strictures caused by ingestion of aluminum phosphide. Natl Med J India. 2006;19:313-4.
10. Benhalima H, Chaudhry MQ, Mills KA, Price NR. Phosphine resistance in stored-product insects collected from various grain storage facilities in Morocco. J Stored Prod Res. 2004;40:241-249. [DOI via Crossref]   
11. Pimentel MAG, Faroni LRD, Totola MR, Guedes RNC. Phosphine resistance, respiration rate and fitness consequences in stored-product insects. Pest Management Science. 2007;63:876-881. [DOI via Crossref]   
12. Daft JL. Fumigants and related chemicals in foods: review of residue findings, contamination sources, and analytical methods. Sci Total Environ. 1991;100:501-18. [DOI via Crossref]   
13. Mehrpour O, Singh S. Rice tablet poisoning: a major concern in Iranian population. Hum Exp Toxicol. 2010;29(8):701-2. [DOI via Crossref]   
14. Easterwood L, Chaffin MK, Marsh PS, Porter B, Barr C. Phosphine intoxication following oral exposure of horses to aluminum phosphide-treated feed. J Am Vet Med Assoc. 2010;236(4):446-50. [DOI via Crossref]   
15. Bogle RG, Theron P, Brooks P, Dargan PI, Redhead J. Aluminium phosphide poisoning. Emerg Med J. 2006; 23(1): e3. [DOI via Crossref]   
16. Dafour DR. Liver disease. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER and Bruns DE, eds. 4th ed. St. Louis, Missouri: Elsevier Saunders; 2006; 1546-1635.
17. Chefurka W, Kashi KP, Bond EJ. The effect of phosphine on electron transport in mitochondria. Pesticide Biochem Physiol. 1976;6(1):65-84. [DOI via Crossref]   
18. Awofadeji S. Nigeria: Food Poisoning: How Many More Will Have to Die? This Day Live. June 2008. Available from URL: http://www.thisdayonline.com/nview.php?id=117427
19. Commision staff working document. Monitoring of Pesticide Residues in Products of Plant Origin in the European Union, Norway, Iceland & Liechtenstein. May 2005. Available from URL:http://ec.europa.eu/food/fvo/specialreports/pesticide_residues/report_2005_en.pdf

This Article Cited By the following articles

Protease inhibition in cowpea pod-sucking bug species (Hemiptera: Heteroptera) using cereal and legume grain extracts
Afr. J. Biochem. Res. 2016; 10(6): 38.

1
 
How to Cite this Article
Pubmed Style

Ayobola Iyanda. Toxicological effects of phosphide powder residue in female rats. Int J Med Sci Public Health. 2013; 2(4): 806-810. doi:10.5455/ijmsph.2013.100620131


Web Style

Ayobola Iyanda. Toxicological effects of phosphide powder residue in female rats. http://www.ijmsph.com/?mno=26023 [Access: October 15, 2018]. doi:10.5455/ijmsph.2013.100620131


AMA (American Medical Association) Style

Ayobola Iyanda. Toxicological effects of phosphide powder residue in female rats. Int J Med Sci Public Health. 2013; 2(4): 806-810. doi:10.5455/ijmsph.2013.100620131



Vancouver/ICMJE Style

Ayobola Iyanda. Toxicological effects of phosphide powder residue in female rats. Int J Med Sci Public Health. (2013), [cited October 15, 2018]; 2(4): 806-810. doi:10.5455/ijmsph.2013.100620131



Harvard Style

Ayobola Iyanda (2013) Toxicological effects of phosphide powder residue in female rats. Int J Med Sci Public Health, 2 (4), 806-810. doi:10.5455/ijmsph.2013.100620131



Turabian Style

Ayobola Iyanda. 2013. Toxicological effects of phosphide powder residue in female rats. International Journal of Medical Science and Public Health, 2 (4), 806-810. doi:10.5455/ijmsph.2013.100620131



Chicago Style

Ayobola Iyanda. "Toxicological effects of phosphide powder residue in female rats." International Journal of Medical Science and Public Health 2 (2013), 806-810. doi:10.5455/ijmsph.2013.100620131



MLA (The Modern Language Association) Style

Ayobola Iyanda. "Toxicological effects of phosphide powder residue in female rats." International Journal of Medical Science and Public Health 2.4 (2013), 806-810. Print. doi:10.5455/ijmsph.2013.100620131



APA (American Psychological Association) Style

Ayobola Iyanda (2013) Toxicological effects of phosphide powder residue in female rats. International Journal of Medical Science and Public Health, 2 (4), 806-810. doi:10.5455/ijmsph.2013.100620131





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Study of psychological stress among undergraduate medical students of government medical college, Surat.
    Priti Solanky, Binita Desai, Abhay Kavishwar, S. L. Kantharia
    Int J Med Sci Public Health. 2012; 1(2): 38-42
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.38-42

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 23 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 6 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 6 times [Click to see citing articles]

  • Migration and health-care access: Barriers to access government health services by migrant tribal community living in an eastern Indian city
    Suchismita Mishra, Yadlapalli S Kusuma, Bontha V Babu
    Int J Med Sci Public Health. 2015; 4(1): 101-108
    » Abstract & References » doi: 10.5455/ijmsph.2015.0110201424
    Cited : 6 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Initial default among tuberculosis patients diagnosed in selected medical colleges of Puducherry: issues and possible interventions
    Divija Pillai, Anil J Purty, Stalin Prabakaran, Zile Singh, Govindarajan Soundappan, Velavan Anandan
    Int J Med Sci Public Health. 2015; 4(7): 957-960
    » Abstract & References » doi: 10.5455/ijmsph.2015.30012015196
    Cited : 6 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 5 times [Click to see citing articles]

  • The surgical approach in huge scrotal lymphedema
    Hiren Dahyabhai Parmar
    Int J Med Sci Public Health. 2013; 2(1): 153-155
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.153-155
    Cited : 5 times [Click to see citing articles]

  • Sugammadex associate persistant bradycardia
    Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu
    Int J Med Sci Public Health. 2014; 3(3): 372-374
    » Abstract & References » doi: 10.5455/ijmsph.2013.251220131
    Cited : 5 times [Click to see citing articles]