E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery

Yogesh Tilkar, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, Neetu Gupta.

Abstract
Background: Adjuvant play very important role in regional anesthesia and search for better adjuvant is still going on.

Objectives: The objectives of this study are to find equipotent doses and to compare the efficacy of two α2 agonists clonidine and dexmedetomidine as an adjuvant in supraclavicular block.

Materials and Methods: A total of 90 patients of the American Society of Anaesthesiologists 1 and 11 of age 20-50 years undergoing elective upper limb surgeries under supraclavicular block divided into three groups: Group N: Received injection bupivacaine 0.5% 15 ml + injection. Lignocaine with adrenaline 2% 15 ml + normal saline 0.5 ml. Group D: 1 μg/kg dexmedetomidine. Group C: 1.5 μg/kg clonidine as studied drug in place of normal saline. Onset, duration of sensory and motor block, duration of analgesia, visual analog scale (VAS) score, hemodynamics, sedation, and other side-effects noted down.

Results: Onset of sensory and motor block in Group D (8.13 2.52 and 12.13 2.90), Group C (7.97 2.58 and 12.47 2.89), and Group N (12.43 2.57 and 17.97 3.06) groups, respectively. Duration of sensory and motor block was 528.2 105.27 and 464.17 93.15 in Group D, 544.97 113.51 and 476.57 105.41 in Group C, and 292 77.4 and 257 75.63 in Group N, respectively. Duration of analgesia was 644.93 118.45 in Group D and 646.93 112.18 in Group C and 352.6 84.39 in Group N. Both studied groups were comparable to each other in above parameters and are significantly better than Group N. VAS score in the post-operative period at 360 min was higher in Group N (5.12 0.68) when compared to Group C (4.5 0.73) and Group D (2.07 0.94), respectively.

Conclusion: Dexmedetomidine and clonidine as an adjuvant to supraclavicular block were found equipotent in the studied doses. However, post-operative VAS was found low in dexmedetomidine group.

Key words: Clonidine; Dexmedetomidine; Supraclavicular Block


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Yogesh Tilkar
Articles by Sangeeta Bansal Agarwal
Articles by Rahul Gupta
Articles by Sanjeevani Karmalkar
Articles by Prabha Khatri
Articles by Neetu Gupta
on Google
on Google Scholar
Article Statistics
 Viewed: 760
Downloaded: 161
Cited: 0

How to Cite this Article
Pubmed Style

Tilkar Y, Agarwal SB, Gupta R, Karmalkar S, Khatri P, Gupta N. The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. Int J Med Sci Public Health. 2017; 6(8): 1314-1319. doi:10.5455/ijmsph.2017.0513713062017


Web Style

Tilkar Y, Agarwal SB, Gupta R, Karmalkar S, Khatri P, Gupta N. The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. http://www.ijmsph.com/?mno=267352 [Access: July 22, 2018]. doi:10.5455/ijmsph.2017.0513713062017


AMA (American Medical Association) Style

Tilkar Y, Agarwal SB, Gupta R, Karmalkar S, Khatri P, Gupta N. The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. Int J Med Sci Public Health. 2017; 6(8): 1314-1319. doi:10.5455/ijmsph.2017.0513713062017



Vancouver/ICMJE Style

Tilkar Y, Agarwal SB, Gupta R, Karmalkar S, Khatri P, Gupta N. The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. Int J Med Sci Public Health. (2017), [cited July 22, 2018]; 6(8): 1314-1319. doi:10.5455/ijmsph.2017.0513713062017



Harvard Style

Tilkar, Y., Agarwal, S. B., Gupta, R., Karmalkar, S., Khatri, P. & Gupta, N. (2017) The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. Int J Med Sci Public Health, 6 (8), 1314-1319. doi:10.5455/ijmsph.2017.0513713062017



Turabian Style

Tilkar, Yogesh, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, and Neetu Gupta. 2017. The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. International Journal of Medical Science and Public Health, 6 (8), 1314-1319. doi:10.5455/ijmsph.2017.0513713062017



Chicago Style

Tilkar, Yogesh, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, and Neetu Gupta. "The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery." International Journal of Medical Science and Public Health 6 (2017), 1314-1319. doi:10.5455/ijmsph.2017.0513713062017



MLA (The Modern Language Association) Style

Tilkar, Yogesh, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, and Neetu Gupta. "The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery." International Journal of Medical Science and Public Health 6.8 (2017), 1314-1319. Print. doi:10.5455/ijmsph.2017.0513713062017



APA (American Psychological Association) Style

Tilkar, Y., Agarwal, S. B., Gupta, R., Karmalkar, S., Khatri, P. & Gupta, N. (2017) The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery. International Journal of Medical Science and Public Health, 6 (8), 1314-1319. doi:10.5455/ijmsph.2017.0513713062017





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Recent update on osteoporosis
    Vijender Agrawal, Dharmendra Gupta
    Int J Med Sci Public Health. 2013; 2(2): 164-168
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.162-166

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Study of psychological stress among undergraduate medical students of government medical college, Surat.
    Priti Solanky, Binita Desai, Abhay Kavishwar, S. L. Kantharia
    Int J Med Sci Public Health. 2012; 1(2): 38-42
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.38-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 21 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 5 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 5 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 5 times [Click to see citing articles]

  • Prevalence and clinical characteristics of autism spectrum disorders in school-age children in Taif- KSA
    Ali H.S Al-Zahrani
    Int J Med Sci Public Health. 2013; 2(3): 578-582
    » Abstract & References » doi: 10.5455/ijmsph.2013.160420133
    Cited : 5 times [Click to see citing articles]

  • Electrocardiographic changes during acute mental stress
    Arpana Bhide, Rajasekhar Durgaprasad, Latheef Kasala, Vanajakshamma Velam, Narendra Hulikal
    Int J Med Sci Public Health. 2016; 5(5): 835-838
    » Abstract & References » doi: 10.5455/ijmsph.2016.19082015137
    Cited : 5 times [Click to see citing articles]

  • Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India
    Vuddandi Prabodh, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, Ravi Shekhara
    Int J Med Sci Public Health. 2012; 1(2): 118-120
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.118-120
    Cited : 4 times [Click to see citing articles]

  • Role of HRCT temporal bone in pre operative evaluation of choesteatoma
    Chintan Shah, Pinal Shah, Satish Shah
    Int J Med Sci Public Health. 2014; 3(1): 69-72
    » Abstract & References » doi: 10.5455/ijmsph.2013.031020131
    Cited : 4 times [Click to see citing articles]