E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India

Suryareshmi B S, Latha K. Abraham, Anna Mathew, John Michael Raj.

Abstract
Background: Pancytopenia is a reduction in all three formed elements of blood, namely - erythrocytes, leukocytes, and platelets. This triad of findings occurs in a number of clinical conditions. The underlying pathology determines the management and prognosis of the patients. Identification of the precise cause is exceptionally challenging and requires a systematic study on the detailed clinical history, drug history, and comorbidities of the patients. Early diagnosis and initiation of prompt therapy will be lifesaving. The causes of pancytopenia vary in different populations and this study will document the etiology of pancytopenia in this region.

Objectives: The objectives of this study were to find out the prevalence and etiological spectrum of pancytopenia in patients diagnosed to have pancytopenia from blood smears done in this institution.

Materials and Methods: This is a cross-sectional, medical record-based study of patients diagnosed to have pancytopenia from peripheral blood smears to find the prevalence of pancytopenia in patients coming to this rural teaching hospital during a 7 months period in 2015.

Results: Of the 2813 blood smears examined in the pathology department of this rural medical college, 61 (2.16%) were diagnosed to have pancytopenia. Of these, 46 patients who fulfilled the selection criteria were recruited to the study. The most common causes of pancytopenia were chronic liver disease (17, 37%), followed by dengue fever (9, 19.6%) and hematological malignancies (4, 8.7%). The common presenting symptoms were fatigue and weakness (36, 76.1%) and fever (26, 56.6%). The most common presenting signs were pallor (9, 19.6), splenomegaly (7, 15.2%), and hepatomegaly (6, 13%).

Conclusion: Chronic liver disease related to alcoholism and dengue fever is the most common causes of pancytopenia in this clinical setting. The common presenting symptoms include fever and fatigue.

Key words: Pancytopenia; Blood Smear; Hepatomegaly; Splenomegaly


 
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Pubmed Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. 2018; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001


Web Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. http://www.ijmsph.com/?mno=273624 [Access: September 23, 2018]. doi:10.5455/ijmsph.2018.0721125122017001


AMA (American Medical Association) Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. 2018; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Vancouver/ICMJE Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. (2018), [cited September 23, 2018]; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Harvard Style

S, S. B., Abraham, L. K., Mathew, A. & Raj, J. M. (2018) The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Turabian Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. 2018. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. International Journal of Medical Science and Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Chicago Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. "The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India." International Journal of Medical Science and Public Health 7 (2018), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



MLA (The Modern Language Association) Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. "The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India." International Journal of Medical Science and Public Health 7.2 (2018), 126-131. Print. doi:10.5455/ijmsph.2018.0721125122017001



APA (American Psychological Association) Style

S, S. B., Abraham, L. K., Mathew, A. & Raj, J. M. (2018) The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. International Journal of Medical Science and Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001





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