E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India

Suryareshmi B S, Latha K. Abraham, Anna Mathew, John Michael Raj.

Abstract
Background: Pancytopenia is a reduction in all three formed elements of blood, namely - erythrocytes, leukocytes, and platelets. This triad of findings occurs in a number of clinical conditions. The underlying pathology determines the management and prognosis of the patients. Identification of the precise cause is exceptionally challenging and requires a systematic study on the detailed clinical history, drug history, and comorbidities of the patients. Early diagnosis and initiation of prompt therapy will be lifesaving. The causes of pancytopenia vary in different populations and this study will document the etiology of pancytopenia in this region.

Objectives: The objectives of this study were to find out the prevalence and etiological spectrum of pancytopenia in patients diagnosed to have pancytopenia from blood smears done in this institution.

Materials and Methods: This is a cross-sectional, medical record-based study of patients diagnosed to have pancytopenia from peripheral blood smears to find the prevalence of pancytopenia in patients coming to this rural teaching hospital during a 7 months period in 2015.

Results: Of the 2813 blood smears examined in the pathology department of this rural medical college, 61 (2.16%) were diagnosed to have pancytopenia. Of these, 46 patients who fulfilled the selection criteria were recruited to the study. The most common causes of pancytopenia were chronic liver disease (17, 37%), followed by dengue fever (9, 19.6%) and hematological malignancies (4, 8.7%). The common presenting symptoms were fatigue and weakness (36, 76.1%) and fever (26, 56.6%). The most common presenting signs were pallor (9, 19.6), splenomegaly (7, 15.2%), and hepatomegaly (6, 13%).

Conclusion: Chronic liver disease related to alcoholism and dengue fever is the most common causes of pancytopenia in this clinical setting. The common presenting symptoms include fever and fatigue.

Key words: Pancytopenia; Blood Smear; Hepatomegaly; Splenomegaly


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Suryareshmi B S
Articles by Latha K. Abraham
Articles by Anna Mathew
Articles by John Michael Raj
on Google
on Google Scholar
Article Statistics
 Viewed: 443
Downloaded: 159
Cited: 0

How to Cite this Article
Pubmed Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. 2018; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001


Web Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. http://www.ijmsph.com/?mno=273624 [Access: June 20, 2018]. doi:10.5455/ijmsph.2018.0721125122017001


AMA (American Medical Association) Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. 2018; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Vancouver/ICMJE Style

S SB, Abraham LK, Mathew A, Raj JM. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health. (2018), [cited June 20, 2018]; 7(2): 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Harvard Style

S, S. B., Abraham, L. K., Mathew, A. & Raj, J. M. (2018) The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. Int J Med Sci Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Turabian Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. 2018. The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. International Journal of Medical Science and Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



Chicago Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. "The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India." International Journal of Medical Science and Public Health 7 (2018), 126-131. doi:10.5455/ijmsph.2018.0721125122017001



MLA (The Modern Language Association) Style

S, Suryareshmi B, Latha K. Abraham, Anna Mathew, and John Michael Raj. "The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India." International Journal of Medical Science and Public Health 7.2 (2018), 126-131. Print. doi:10.5455/ijmsph.2018.0721125122017001



APA (American Psychological Association) Style

S, S. B., Abraham, L. K., Mathew, A. & Raj, J. M. (2018) The etiological spectrum of pancytopenia diagnosed from blood smears examined in the pathology department of a rural tertiary care centre in South India. International Journal of Medical Science and Public Health, 7 (2), 126-131. doi:10.5455/ijmsph.2018.0721125122017001





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Recent update on osteoporosis
    Vijender Agrawal, Dharmendra Gupta
    Int J Med Sci Public Health. 2013; 2(2): 164-168
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.162-166

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Study of psychological stress among undergraduate medical students of government medical college, Surat.
    Priti Solanky, Binita Desai, Abhay Kavishwar, S. L. Kantharia
    Int J Med Sci Public Health. 2012; 1(2): 38-42
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.38-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 21 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 5 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 5 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 5 times [Click to see citing articles]

  • Prevalence and clinical characteristics of autism spectrum disorders in school-age children in Taif- KSA
    Ali H.S Al-Zahrani
    Int J Med Sci Public Health. 2013; 2(3): 578-582
    » Abstract & References » doi: 10.5455/ijmsph.2013.160420133
    Cited : 5 times [Click to see citing articles]

  • Electrocardiographic changes during acute mental stress
    Arpana Bhide, Rajasekhar Durgaprasad, Latheef Kasala, Vanajakshamma Velam, Narendra Hulikal
    Int J Med Sci Public Health. 2016; 5(5): 835-838
    » Abstract & References » doi: 10.5455/ijmsph.2016.19082015137
    Cited : 5 times [Click to see citing articles]

  • Importance of cardiac marker enzymes (Aspartate transaminase and troponin I) in acute myocardial infarction: A case-control study from South India
    Vuddandi Prabodh, Deva Prakash, Godi Sudhakar, Yeruva Reddy, Nadella Chowdary, Sripada Desai, Ravi Shekhara
    Int J Med Sci Public Health. 2012; 1(2): 118-120
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.118-120
    Cited : 4 times [Click to see citing articles]

  • Role of HRCT temporal bone in pre operative evaluation of choesteatoma
    Chintan Shah, Pinal Shah, Satish Shah
    Int J Med Sci Public Health. 2014; 3(1): 69-72
    » Abstract & References » doi: 10.5455/ijmsph.2013.031020131
    Cited : 4 times [Click to see citing articles]