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Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India

Debahuti Sabhapandit, Wihiwot Valarie Lyngdoh, Ishani Bora, Abhijit Prasad, Koushik Debnath, Elantamilan D.

Abstract
Background: Candidemia is gaining significance worldwide and is the fourth most common cause of bloodstream infections (BSI) with mortality ranging from 5% to 71%.

Objectives: To determine the prevalence of candidemia and characterize the non-albicans candida (NAC) causing BSI.

Materials and Methods: The study was conducted in the department of microbiology for a period of 2 years (January 2014-December 2015). Blood samples received were cultured in brainheart infusion broth. Subcultures were done in Sabouraud Dextrose Agar and Sabouraud Chloramphenicol Cycloheximide Agar. For identification of isolates, Gram stain, germ tube test, urea hydrolysis, cornmeal agar morphology, and sugar assimilation test were performed. Antifungal susceptibility testing was determined by Vitek 2 compact system using AST YS 06 Cards.

Results: During the study period, a total of 4123 blood samples were received, of which 786 samples were positive. Among the 786 positive samples, 739 (94%) samples showed bacterial growth and 47 (6%) samples showed growth of Candida spp. The prevalence of NAC was 32 (70%) and rest 15 (30%) was Candida albicans. Most of the NAC species showed resistance to fluconazole, voriconazole, caspofungin, micafungin, and amphotericin B as compared to C. albicans.

Conclusion: The study highlights the change in epidemiology in the species distribution of Candida. There is a rise in infections by NAC species as compared to those by C. albicans. Early and regular species identification and antifungal testing is necessary to decrease the mortality associated with it.

Key words: Non-albicans Candida; Bloodstream Infection; Candidemia; Antifungals


 
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How to Cite this Article
Pubmed Style

Sabhapandit D, Lyngdoh WV, Bora I, Prasad A, Debnath K, D E. Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. Int J Med Sci Public Health. 2017; 6(11): 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



Web Style

Sabhapandit D, Lyngdoh WV, Bora I, Prasad A, Debnath K, D E. Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. www.scopemed.org/?mno=275063 [Access: November 19, 2017]. doi:10.5455/ijmsph.2017.0823622092017



AMA (American Medical Association) Style

Sabhapandit D, Lyngdoh WV, Bora I, Prasad A, Debnath K, D E. Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. Int J Med Sci Public Health. 2017; 6(11): 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



Vancouver/ICMJE Style

Sabhapandit D, Lyngdoh WV, Bora I, Prasad A, Debnath K, D E. Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. Int J Med Sci Public Health. (2017), [cited November 19, 2017]; 6(11): 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



Harvard Style

Sabhapandit, D., Lyngdoh, W. V., Bora, I., Prasad, A., Debnath, K. & D, E. (2017) Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. Int J Med Sci Public Health, 6 (11), 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



Turabian Style

Sabhapandit, Debahuti, Wihiwot Valarie Lyngdoh, Ishani Bora, Abhijit Prasad, Koushik Debnath, and Elantamilan D. 2017. Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. International Journal of Medical Science and Public Health , 6 (11), 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



Chicago Style

Sabhapandit, Debahuti, Wihiwot Valarie Lyngdoh, Ishani Bora, Abhijit Prasad, Koushik Debnath, and Elantamilan D. "Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India." International Journal of Medical Science and Public Health 6 (2017), 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



MLA (The Modern Language Association) Style

Sabhapandit, Debahuti, Wihiwot Valarie Lyngdoh, Ishani Bora, Abhijit Prasad, Koushik Debnath, and Elantamilan D. "Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India." International Journal of Medical Science and Public Health 6.11 (2017), 1620-1625. Print. doi:10.5455/ijmsph.2017.0823622092017



APA (American Psychological Association) Style

Sabhapandit, D., Lyngdoh, W. V., Bora, I., Prasad, A., Debnath, K. & D, E. (2017) Prevalence of non-albicans candidemia in a tertiary care hospital in Northeast India. International Journal of Medical Science and Public Health , 6 (11), 1620-1625. doi:10.5455/ijmsph.2017.0823622092017



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Retraction notice [Dec 03, 2016]
Retraction notice [Mar 02, 2015]
Submission of article [Jul 22, 2012]


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