E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Dynamics of airway functions in untreated hypothyroidism

Geetanjali Purohit, Trushna Shah, Jaman Mohan Harsoda.

Abstract
Background: Hypothyroidism is a hormonal disorder, more prevalent in females, affects respiratory systems at early stage.

Objectives: Present study was carried out to observe the expiratory and inspiratory dynamics of airway functions in recently diagnosed hypothyroid females without medication and its comparison with hypothyroid females with hormonal therapy and euthyroid females. Parameters studied were forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1%, forced inspiratory vital capacity (FIVC), FIV1, FIV1%, forced expiratory flow (FEF25-75%), FEF0.2-1.2%, FEF25%, FEF50%, FEF75%, peak expiratory flow (PEF), and peak inspiratory flow.

Materials and Methods: Twenty-one (n = 21) recently diagnosed hypothyroid women without medication (Group-1) and 19 hypothyroid women taking medication for the last 6-8 months (Group-2) were studied. Hypothyroidism was diagnosed on the basis of serum thyroid-stimulating hormone level (<5IU). Total 22 apparently euthyroid subjects (Group-3) were studied as control. Data were analyzed by one-way ANOVA with post hoc Tukey honestly significant difference and alpha error was set at 5% level.

Results: The mean values for FVC, FEV1, FIVC, and FIV1 were less in Group-1 in compare to Group-2 and 3 and the differences were statistically significant (P < 0.05). Large airway functions as FEF25-75%, FEF25%, and PEF also found the same decrease as above. Small airway functions as FEF50%, FEF75% may preserve except FEF 0.2-1.2.

Conclusion: Untreated hypothyroidism extremely alters the respiratory dynamics and can be reversed by hormonal therapy. Large airway functions get diminished, but small airway functions remain unaltered. Study in large population with more disease duration will help to determine the severity of disease. Lung functions can be used as a tool to assess the effectiveness of treatment of hypothyroidism.

Key words: Forced Vital Capacity; Forced Expiratory Volume 1; Peak Expiratory Flow; Thyroid-stimulating Hormone; Hypothyroid; Euthyroid


 
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How to Cite this Article
Pubmed Style

Purohit G, Shah T, Harsoda JM. Dynamics of airway functions in untreated hypothyroidism. Int J Med Sci Public Health. 2017; 6(12): 1713-1717. doi:10.5455/ijmsph.2017.092741112017


Web Style

Purohit G, Shah T, Harsoda JM. Dynamics of airway functions in untreated hypothyroidism. http://www.ijmsph.com/?mno=275904 [Access: August 21, 2018]. doi:10.5455/ijmsph.2017.092741112017


AMA (American Medical Association) Style

Purohit G, Shah T, Harsoda JM. Dynamics of airway functions in untreated hypothyroidism. Int J Med Sci Public Health. 2017; 6(12): 1713-1717. doi:10.5455/ijmsph.2017.092741112017



Vancouver/ICMJE Style

Purohit G, Shah T, Harsoda JM. Dynamics of airway functions in untreated hypothyroidism. Int J Med Sci Public Health. (2017), [cited August 21, 2018]; 6(12): 1713-1717. doi:10.5455/ijmsph.2017.092741112017



Harvard Style

Purohit, G., Shah, T. & Harsoda, J. M. (2017) Dynamics of airway functions in untreated hypothyroidism. Int J Med Sci Public Health, 6 (12), 1713-1717. doi:10.5455/ijmsph.2017.092741112017



Turabian Style

Purohit, Geetanjali, Trushna Shah, and Jaman Mohan Harsoda. 2017. Dynamics of airway functions in untreated hypothyroidism. International Journal of Medical Science and Public Health, 6 (12), 1713-1717. doi:10.5455/ijmsph.2017.092741112017



Chicago Style

Purohit, Geetanjali, Trushna Shah, and Jaman Mohan Harsoda. "Dynamics of airway functions in untreated hypothyroidism." International Journal of Medical Science and Public Health 6 (2017), 1713-1717. doi:10.5455/ijmsph.2017.092741112017



MLA (The Modern Language Association) Style

Purohit, Geetanjali, Trushna Shah, and Jaman Mohan Harsoda. "Dynamics of airway functions in untreated hypothyroidism." International Journal of Medical Science and Public Health 6.12 (2017), 1713-1717. Print. doi:10.5455/ijmsph.2017.092741112017



APA (American Psychological Association) Style

Purohit, G., Shah, T. & Harsoda, J. M. (2017) Dynamics of airway functions in untreated hypothyroidism. International Journal of Medical Science and Public Health, 6 (12), 1713-1717. doi:10.5455/ijmsph.2017.092741112017





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