E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K.

Abstract
Background: Sputum smear conversion rate (SCR) at the intensive phase (IP) of antitubercular treatment is an indicator of patientís response to treatment as well as the performance of tuberculosis (TB) control program, especially in resource limited settings.

Objectives: The objectives of this study are (1) to identify medicosocial factors associated with a delay in sputum smear conversion at the end of IP and (2) to find the influence of sputum smear conversion on treatment outcome.

Materials and Methods: A prospective study was conducted in all six Designated Microscopy Centers (DMCs) of Davangere TB Unit, Karnataka, for 1 year. About 216 new sputum smear-positive pulmonary TB patients aged ‚Č•15 years who were diagnosed in these DMCs and registered under Revised National TB Control Program constituted the study sample. Data were collected by direct interview method using a pretested, semi-structured questionnaire.

Results: Majority of the study subjects were males, residing in urban areas. The overall sputum SCR was 85.8%. Univariate analysis revealed that elderly age, stigmatization, tobacco smoking, diabetes mellitus, and pretreatment sputum smear grading were significantly associated with delayed sputum smear conversion at the end of IP. In multivariate analysis, tobacco smoking (adjusted odds ratio [aOR] [95% confidence interval (CI)]: 2.18 [1.03-4.61]), diabetes mellitus (aOR [95% CI]: 3.43 [1.27-9.31]), and higher pretreatment smear grading of 3+ (aOR [95% CI]: 2.73 [1.27-5.85]) emerged as independent predictors of delayed sputum smear conversion. Delayed sputum smear conversion was also found to be significantly linked with unfavorable treatment outcomes.

Conclusion: Sputum SCR among new smear-positive pulmonary TB patients in Davangere TB Unit was satisfactory. Patients with identified risk factors were less likely to achieve sputum smear conversion and need to be monitored more closely to prevent unfavorable outcomes.

Key words: Designated Microscopy Center; New Smear Positive; Pulmonary Tuberculosis; Sputum Smear Conversion; Smear Conversion Rate; Sputum Smear Grading


 
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Pubmed Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. Int J Med Sci Public Health. 2017; 6(11): 1565-1571. doi:10.5455/ijmsph.2017.0824913092017


Web Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. http://www.ijmsph.com/?mno=276627 [Access: December 17, 2018]. doi:10.5455/ijmsph.2017.0824913092017


AMA (American Medical Association) Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. Int J Med Sci Public Health. 2017; 6(11): 1565-1571. doi:10.5455/ijmsph.2017.0824913092017



Vancouver/ICMJE Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. Int J Med Sci Public Health. (2017), [cited December 17, 2018]; 6(11): 1565-1571. doi:10.5455/ijmsph.2017.0824913092017



Harvard Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K (2017) Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. Int J Med Sci Public Health, 6 (11), 1565-1571. doi:10.5455/ijmsph.2017.0824913092017



Turabian Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. 2017. Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. International Journal of Medical Science and Public Health, 6 (11), 1565-1571. doi:10.5455/ijmsph.2017.0824913092017



Chicago Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. "Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit." International Journal of Medical Science and Public Health 6 (2017), 1565-1571. doi:10.5455/ijmsph.2017.0824913092017



MLA (The Modern Language Association) Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K. "Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit." International Journal of Medical Science and Public Health 6.11 (2017), 1565-1571. Print. doi:10.5455/ijmsph.2017.0824913092017



APA (American Psychological Association) Style

Anandaraj R, Anurupa M S, Kavithai P, Rashmi B M, Ranjitha A, Raghavendra S K (2017) Factors influencing delay in sputum smear conversion among new smear-positive pulmonary tuberculosis patients of Davangere tuberculosis unit. International Journal of Medical Science and Public Health, 6 (11), 1565-1571. doi:10.5455/ijmsph.2017.0824913092017





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