E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq.

Abstract
Background: Direct laryngoscopy and intubation are associated with the pressor response which leads to increase in blood pressure (BP) and heart rate (HR) which may be tolerated by young healthy individuals but can prove detrimental in elderly and comorbid patients. Hence, some premedication agents are administered to suppress these responses.

Objectives: In this study, we compared gabapentin and combination of gabapentin and labetalol with a placebo group to study their effect on attenuation of these pressor responses.

Materials and Methods: A total of 90 patients belonging to American Society of Anesthesiologists Class I and II were divided into three Groups A, B, and C of 30 patients each. 1 h before induction of anesthesia patients in Group A received gabapentin 800 mg and in Group B received 400 mg of gabapentin plus 50 mg of labetalol orally, while patients in Group C did not receive any drug and acted as control. Mean arterial pressure (MAP) and HR were recorded in all the three groups at baseline and at 0, 1, 3, 5, and 10 min after tracheal intubation.

Results: Demographic characteristics were comparable in all the three groups. The baseline HR and MAP were also comparable in all the three groups and were statistically insignificant (P > 0.05). However, after tracheal intubation, there was significant increase in HR and MAP in the control Group (C), whereas in Group A and B the response was attenuated and was statistically significant (P = 0.05). Among the two study groups, BP was better attenuated by gabapentin, whereas the combination of gabapentin and labetalol abolishes HR response better.

Conclusion: We conclude gabapentin alone and in combination with labetalol attenuates the hemodynamic response to laryngoscopy and intubation.

Key words: Laryngoscopy; Intubation; Gabapentin; Labetalol; Pressor Response


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Shaista Yaqoob
Articles by Tantry Tariq Gani
Articles by Aabid Hussain Mir
Articles by Abida Yousuf
Articles by Abdul Waheed Mir
Articles by Shahnawaz Khaliq
on Google
on Google Scholar
Article Statistics
 Viewed: 940
Downloaded: 345
Cited: 0

How to Cite this Article
Pubmed Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. 2018; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017


Web Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. http://www.ijmsph.com/?mno=278282 [Access: December 10, 2018]. doi:10.5455/ijmsph.2018.0926825112017


AMA (American Medical Association) Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. 2018; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017



Vancouver/ICMJE Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health. (2018), [cited December 10, 2018]; 7(1): 58-62. doi:10.5455/ijmsph.2018.0926825112017



Harvard Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq (2018) A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. Int J Med Sci Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017



Turabian Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. 2018. A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. International Journal of Medical Science and Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017



Chicago Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. "A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation." International Journal of Medical Science and Public Health 7 (2018), 58-62. doi:10.5455/ijmsph.2018.0926825112017



MLA (The Modern Language Association) Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq. "A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation." International Journal of Medical Science and Public Health 7.1 (2018), 58-62. Print. doi:10.5455/ijmsph.2018.0926825112017



APA (American Psychological Association) Style

Shaista Yaqoob, Tantry Tariq Gani, Aabid Hussain Mir, Abida Yousuf, Abdul Waheed Mir, Shahnawaz Khaliq (2018) A comparative randomized study to evaluate the effect of gabapentin alone and in combination with labetalol in attenuating the pressor response to direct laryngoscopy and intubation. International Journal of Medical Science and Public Health, 7 (1), 58-62. doi:10.5455/ijmsph.2018.0926825112017





Most Viewed Articles
  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Maternal and fetal outcome in oligohydramnios- Study of 100 cases
    Krishna Jagatia, Nisha Singh, Sachin Patel
    Int J Med Sci Public Health. 2013; 2(3): 724-727
    » Abstract & References » doi: 10.5455/ijmsph.2013.070520132

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Prevalence and pattern of substance abuse among school childern in nothern India: A rapid assesment study
    Syed Shuja Qadri, RKD Goel, Jagjeet Singh, Surendra Kumar Ahluwalia, Rambha Pathak, Humaira Bashir
    Int J Med Sci Public Health. 2013; 2(2): 273-282
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.271-280

  • Most Downloaded
  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Gunthers with haemolytic anaemia extremly rare: A case report
    Nilesh Kumar, Ankur Varshney, Arvind Anand, Dibyaranjan Behera, Ravi Anand, Ashutosh Tiwari
    Int J Med Sci Public Health. 2013; 2(2): 472-474
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.313-315

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Minor disorder of pregnancy and its home management
    Lata Gururani, Atul Kumar, Gomathi Mahalingam
    Int J Med Sci Public Health. 2016; 5(4): 684-687
    » Abstract & References » doi: 10.5455/ijmsph.2016.03082015111

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6

  • Association between serum ferritin and thyroid hormone profile in hypothyroidism
    Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair
    Int J Med Sci Public Health. 2015; 4(6): 863-865
    » Abstract & References » doi: 10.5455/ijmsph.2015.24012015174

  • Effect of sleep deprivation on the attitude and performance of medical students, Riyadh, Saudi Arabia
    Hussein Saad Amin, Ibrahim Salamah Almazroua, Abdullah Sulaiman Alsahlan, Mohammed Abdullah Alrishan, Houssam Mourad Elmourad, Mohammed Mansour Alotaibi, Abdulaziz Ibrahim Almohaisin
    Int J Med Sci Public Health. 2016; 5(3): 575-580
    » Abstract & References » doi: 10.5455/ijmsph.2016.17112015207

  • Patient satisfaction about health care services: A cross sectional study of patients who visit the outpatient department of a civil hospital at Surendranagar, Gujarat
    Krupal Joshi, Kishor Sochaliya, Shyamal Purani, Girija Kartha
    Int J Med Sci Public Health. 2013; 2(3): 659-663
    » Abstract & References » doi: 10.5455/ijmsph.2013.250420131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 23 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 13 times [Click to see citing articles]

  • Clinico-microbiological profile of women with vaginal discharge in a tertiary care hospital of northern India
    Varsha Chaudhary, Ved Prakesh, Kian Agarwal, Vijender Kumar Agrawal, Arun Singh, Sachin Pandey
    Int J Med Sci Public Health. 2012; 1(2): 75-80
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.75-80
    Cited : 6 times [Click to see citing articles]

  • Correlation between obesity and cardio respiratory fitness
    Prabha Setty, BV Padmanabha, BR Doddamani
    Int J Med Sci Public Health. 2013; 2(2): 300-304
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.298-302
    Cited : 6 times [Click to see citing articles]

  • Migration and health-care access: Barriers to access government health services by migrant tribal community living in an eastern Indian city
    Suchismita Mishra, Yadlapalli S Kusuma, Bontha V Babu
    Int J Med Sci Public Health. 2015; 4(1): 101-108
    » Abstract & References » doi: 10.5455/ijmsph.2015.0110201424
    Cited : 6 times [Click to see citing articles]

  • Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile
    Sachin Chandrakant Deorukhkar, Santosh Saini
    Int J Med Sci Public Health. 2013; 2(3): 533-538
    » Abstract & References » doi: 10.5455/ijmsph.2013.080320131
    Cited : 6 times [Click to see citing articles]

  • Initial default among tuberculosis patients diagnosed in selected medical colleges of Puducherry: issues and possible interventions
    Divija Pillai, Anil J Purty, Stalin Prabakaran, Zile Singh, Govindarajan Soundappan, Velavan Anandan
    Int J Med Sci Public Health. 2015; 4(7): 957-960
    » Abstract & References » doi: 10.5455/ijmsph.2015.30012015196
    Cited : 6 times [Click to see citing articles]

  • Knowledge, Attitude, and Practices (KAP) study on HIV / AIDS among HIV patients, care givers and general population in north-eastern part of India.
    L P Meena, S K Pandey, M Rai, Anju Bharti, Shyam Sunder
    Int J Med Sci Public Health. 2013; 2(1): 36-42
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.36-42
    Cited : 5 times [Click to see citing articles]

  • The surgical approach in huge scrotal lymphedema
    Hiren Dahyabhai Parmar
    Int J Med Sci Public Health. 2013; 2(1): 153-155
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.153-155
    Cited : 5 times [Click to see citing articles]

  • Sugammadex associate persistant bradycardia
    Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu
    Int J Med Sci Public Health. 2014; 3(3): 372-374
    » Abstract & References » doi: 10.5455/ijmsph.2013.251220131
    Cited : 5 times [Click to see citing articles]