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Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC

Abhishek Kumar Jain, Savita Bharat Jain, K P Ranjan, Vaibhav Misra, Shashi Gandhi.

Abstract
Background: Throughout the world multidrug-resistant healthcare-associated infections (HAI) are one of the leading causes of morbidity and mortality among hospitalized patients, leading to a major burden on public health system of any country. An intensive care unit (ICU) patient has five- to seven-folds higher risk of HAI and ICU infections contribute to 2025% of all HAI.

Objective: This prospective study was designed to isolate and identify the bacterial etiology, their antimicrobial susceptibility pattern and to detect the production of the metallo β-lactamases (MBL) and AmpC-β-lactamases in multidrug-resistant gram negative isolates.

Material and Methods: The study was conducted for the period of 1 year. During the period a total 196 samples were collected and processed as per Clinical and Laboratory Standards Institute guidelines.

Result: The majority of bacterial isolates causing HAI were found to be Gram-negative bacilli (73.68%). Acinetobacter species followed by Pseudomonas aeruginosa, Escherichia coli, Citrobacter species, Klebsiella species, and Enterobacter species, respectively. Gram-positive cocci were accounted 26.31% isolates. All isolates were multidrugresistant. Among Gram negative bacilli, 38.10% AmpC producer, 35.71% MBL, and 16.67% were coproducer of AmpC and MBL.

Conclusion: Microbiological profile of infection in ICU of our institute was multidrug-resistant, and in many isolates, drug resistance was due to the production of MBL and AmpC-β-lactamases, which represents basic information for future monitoring of HAI and could be repeated periodically. Thus, the future prevention program should focus on patients with a longer length of stay and those with invasive devices.

Key words: Healthcare-Associated Infections; metallo β-lactamases; AmpC-β-lactamases; ICU


 
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How to Cite this Article
Pubmed Style

Jain AK, Jain SB, Ranjan KP, Misra V, Gandhi S. Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018


Web Style

Jain AK, Jain SB, Ranjan KP, Misra V, Gandhi S. Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. http://www.ijmsph.com/?mno=279909 [Access: February 17, 2018]. doi:10.5455/ijmsph.2018.1027919012018


AMA (American Medical Association) Style

Jain AK, Jain SB, Ranjan KP, Misra V, Gandhi S. Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018



Vancouver/ICMJE Style

Jain AK, Jain SB, Ranjan KP, Misra V, Gandhi S. Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018



Harvard Style

Jain, A. K., Jain, S. B., Ranjan, K. P., Misra, V. & Gandhi, S. (2018) Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018



Turabian Style

Jain, Abhishek Kumar, Savita Bharat Jain, K P Ranjan, Vaibhav Misra, and Shashi Gandhi. 2018. Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018



Chicago Style

Jain, Abhishek Kumar, Savita Bharat Jain, K P Ranjan, Vaibhav Misra, and Shashi Gandhi. "Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC." doi:10.5455/ijmsph.2018.1027919012018



MLA (The Modern Language Association) Style

Jain, Abhishek Kumar, Savita Bharat Jain, K P Ranjan, Vaibhav Misra, and Shashi Gandhi. "Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC." doi:10.5455/ijmsph.2018.1027919012018



APA (American Psychological Association) Style

Jain, A. K., Jain, S. B., Ranjan, K. P., Misra, V. & Gandhi, S. (2018) Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo β-lactamases and AmpC. doi:10.5455/ijmsph.2018.1027919012018



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Retraction notice [Dec 03, 2016]
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