E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Evaluation of antinociceptive activity of minocycline: An experimental study

Mangal Kishanrao Choure, Rakesh Ramratan Jadhav.

Abstract
Background: Recently, some studies have shown that minocycline may have pleiotropic biologic activities besides its antimicrobial activity. Minocycline is also an inhibitor of microglial cell activation, an effect that may contribute to its antinociceptive activity, as these cells release several mediators, including cytokines and eicosanoids, which enhance synaptic transmission in the central nervous system.

Objectives: The objective of this study is to evaluate antinociceptive activity of minocycline by tail-flick response and acetic acid-induced writhing methods.

Materials and Methods: Wistar rats of either sex weighing 180250 g and Swiss mice weighing 2530 g were used. Analgesic activity of minocycline (100 mg/kg i.p.) was evaluated and compared with tramadol (10 mg/kg i.p.) and aspirin (100 mg/kg i.p.) using acetic acid-induced writhing method and tail-flick response method of analgesia.

Results: In acetic acid-induced writhing model of analgesia, the action of minocycline (100 mg/kg i.p.) was significantly more than the control group, but it was less when compared to aspirin. Furthermore, in tail-flick model of analgesia, it showed significant analgesic activity but was less than that of aspirin and tramadol.

Conclusion: Minocycline possesses analgesic activity. However, further studies need to be carried out to evaluate its analgesic activity.

Key words: Antinociception; Minocycline; Acetic Acid-induced Writhing; Tail-flick


 
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Pubmed Style

Choure MK, Jadhav RR. Evaluation of antinociceptive activity of minocycline: An experimental study. Int J Med Sci Public Health. 2018; 7(4): 245-248. doi:10.5455/ijmsph.2018.1234424012018


Web Style

Choure MK, Jadhav RR. Evaluation of antinociceptive activity of minocycline: An experimental study. http://www.ijmsph.com/?mno=286831 [Access: April 21, 2018]. doi:10.5455/ijmsph.2018.1234424012018


AMA (American Medical Association) Style

Choure MK, Jadhav RR. Evaluation of antinociceptive activity of minocycline: An experimental study. Int J Med Sci Public Health. 2018; 7(4): 245-248. doi:10.5455/ijmsph.2018.1234424012018



Vancouver/ICMJE Style

Choure MK, Jadhav RR. Evaluation of antinociceptive activity of minocycline: An experimental study. Int J Med Sci Public Health. (2018), [cited April 21, 2018]; 7(4): 245-248. doi:10.5455/ijmsph.2018.1234424012018



Harvard Style

Choure, M. K. & Jadhav, R. R. (2018) Evaluation of antinociceptive activity of minocycline: An experimental study. Int J Med Sci Public Health, 7 (4), 245-248. doi:10.5455/ijmsph.2018.1234424012018



Turabian Style

Choure, Mangal Kishanrao, and Rakesh Ramratan Jadhav. 2018. Evaluation of antinociceptive activity of minocycline: An experimental study. International Journal of Medical Science and Public Health, 7 (4), 245-248. doi:10.5455/ijmsph.2018.1234424012018



Chicago Style

Choure, Mangal Kishanrao, and Rakesh Ramratan Jadhav. "Evaluation of antinociceptive activity of minocycline: An experimental study." International Journal of Medical Science and Public Health 7 (2018), 245-248. doi:10.5455/ijmsph.2018.1234424012018



MLA (The Modern Language Association) Style

Choure, Mangal Kishanrao, and Rakesh Ramratan Jadhav. "Evaluation of antinociceptive activity of minocycline: An experimental study." International Journal of Medical Science and Public Health 7.4 (2018), 245-248. Print. doi:10.5455/ijmsph.2018.1234424012018



APA (American Psychological Association) Style

Choure, M. K. & Jadhav, R. R. (2018) Evaluation of antinociceptive activity of minocycline: An experimental study. International Journal of Medical Science and Public Health, 7 (4), 245-248. doi:10.5455/ijmsph.2018.1234424012018





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