E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India

Vinay Yadav, Milan Jaiswal, Surabhi Pandey.

Abstract
Background: Cervical cancer ranks as the 2nd most common cancer among Indian women between 15 and 44 years of age. The secondary biomarker p53 has been studied at various centers in the world and has been found to be deregulated in cervical cancers.

Objective: This study was undertaken to observe the expression and association of p53 and grades of p53 in premalignant and malignant cervical lesions and also with their histopathological subtypes.

Materials and Methods: The present prospective study was conducted, from January 2016 to December 2016. Patients with premalignant and malignant cervical lesions of epithelial origin were included, while those with other pathological entities were excluded. A total of 53 patients were finally enroled for this study. Cases with p53 expression in more than 5% cells were considered positive for p53 overexpression.

Results: The mean of p53 expression was higher in malignant lesions (13.29 16.00) when compared to premalignant lesions (1.12 2.23) and the result was statistically significant (P = 0.019). No statistically significant association (P = 0.875) was found between types of premalignant lesions and p53 overexpression as well as types of malignant lesions and p53 expression.

Conclusion: In the present study, much higher percentage of p53 overexpression is observed in malignant than premalignant lesions, the difference being statistically significant (P = 0.009). Mean p53 expression in the malignant lesions is also higher than premalignant lesions. p53 expression is therefore a suggested marker for differentiating malignant from premalignant lesions.

Key words: p53 Expression; Premalignant Cervical Lesion; Cervical Cancer


 
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How to Cite this Article
Pubmed Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. Int J Med Sci Public Health. 2018; 7(3): 216-221. doi:10.5455/ijmsph.2018.0100612012018


Web Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. http://www.ijmsph.com/?mno=287449 [Access: November 21, 2018]. doi:10.5455/ijmsph.2018.0100612012018


AMA (American Medical Association) Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. Int J Med Sci Public Health. 2018; 7(3): 216-221. doi:10.5455/ijmsph.2018.0100612012018



Vancouver/ICMJE Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. Int J Med Sci Public Health. (2018), [cited November 21, 2018]; 7(3): 216-221. doi:10.5455/ijmsph.2018.0100612012018



Harvard Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey (2018) A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. Int J Med Sci Public Health, 7 (3), 216-221. doi:10.5455/ijmsph.2018.0100612012018



Turabian Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. 2018. A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. International Journal of Medical Science and Public Health, 7 (3), 216-221. doi:10.5455/ijmsph.2018.0100612012018



Chicago Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. "A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India." International Journal of Medical Science and Public Health 7 (2018), 216-221. doi:10.5455/ijmsph.2018.0100612012018



MLA (The Modern Language Association) Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey. "A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India." International Journal of Medical Science and Public Health 7.3 (2018), 216-221. Print. doi:10.5455/ijmsph.2018.0100612012018



APA (American Psychological Association) Style

Vinay Yadav, Milan Jaiswal, Surabhi Pandey (2018) A comparative study of p53 expression in premalignant and malignant cervical lesions at a tertiary care institute of Rohilkhand region, India. International Journal of Medical Science and Public Health, 7 (3), 216-221. doi:10.5455/ijmsph.2018.0100612012018





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