E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile

Sachin Chandrakant Deorukhkar, Santosh Saini.

Cited by (6)

Abstract
Background: The change in epidemiology and antifungal susceptibility has generated interest of Clinical Microbiologists in identification of Candida up to species level along with antifungal susceptibility pattern. Non-albicans Candida (NAC) has emerged as an important opportunist pathogen. Extracellular hydrolytic enzymes are one of the important virulence attributes of Candida species.

Aims & Objective: The present study aimed to determine the species distribution, virulence factors and antifungal susceptibility profile of NAC spp. isolated from various clinical specimens.

Material and Methods: Speciation of Candida was done by assessing the germ tube formation, assimilation and fermentation of sugars and colony color on HICHROM Candida agar. In-vitro extracellular hydrolytic enzymes production in NAC spp. was assessed. Antifungal susceptibility testing of the isolates was performed by Hicomb minimum inhibitory concentration (MIC) test.

Results: Majority of the isolates were obtained from urine sample (35.6%). C. tropicalis (29.4%) was the major isolate. Maximum extracellular hydrolytic enzymes activity was seen in C. tropicalis. A total of 79 (27.3%) isolates were resistant to fluconazole. Amphotericin B resistance was noted in 17 (5.8%) isolates.

Conclusion: NAC spp. cannot be overlooked as mere containment or non-pathogenic commensals as most of them show reduced susceptibility to commonly used antifungal drugs. Extracellular hydrolytic enzymatic activity of NAC Spp. would be an important tool to prove the relation between the infective species of Candida and infection.

Key words: Antifungal susceptibility; Extracellular hydrolytic enzymes; Fluconazole; Non- albicans Candida species.


 
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How to Cite this Article
Pubmed Style

Deorukhkar SC, Saini S. Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. Int J Med Sci Public Health. 2013; 2(3): 533-538. doi:10.5455/ijmsph.2013.080320131


Web Style

Deorukhkar SC, Saini S. Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. http://www.ijmsph.com/?mno=33020 [Access: September 21, 2018]. doi:10.5455/ijmsph.2013.080320131


AMA (American Medical Association) Style

Deorukhkar SC, Saini S. Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. Int J Med Sci Public Health. 2013; 2(3): 533-538. doi:10.5455/ijmsph.2013.080320131



Vancouver/ICMJE Style

Deorukhkar SC, Saini S. Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. Int J Med Sci Public Health. (2013), [cited September 21, 2018]; 2(3): 533-538. doi:10.5455/ijmsph.2013.080320131



Harvard Style

Deorukhkar, S. C. & Saini, S. (2013) Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. Int J Med Sci Public Health, 2 (3), 533-538. doi:10.5455/ijmsph.2013.080320131



Turabian Style

Deorukhkar, Sachin Chandrakant, and Santosh Saini. 2013. Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. International Journal of Medical Science and Public Health, 2 (3), 533-538. doi:10.5455/ijmsph.2013.080320131



Chicago Style

Deorukhkar, Sachin Chandrakant, and Santosh Saini. "Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile." International Journal of Medical Science and Public Health 2 (2013), 533-538. doi:10.5455/ijmsph.2013.080320131



MLA (The Modern Language Association) Style

Deorukhkar, Sachin Chandrakant, and Santosh Saini. "Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile." International Journal of Medical Science and Public Health 2.3 (2013), 533-538. Print. doi:10.5455/ijmsph.2013.080320131



APA (American Psychological Association) Style

Deorukhkar, S. C. & Saini, S. (2013) Non albicans Candida species: its isolation pattern, species distribution, virulence factors and antifungal susceptibility profile. International Journal of Medical Science and Public Health, 2 (3), 533-538. doi:10.5455/ijmsph.2013.080320131





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