E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi.

Cited by (1)

Abstract
Background: Lymphocytes play an important role in wound healing and the removal of circulating T lymphocytes inhibits the healing cascade. Decreased stimulation of survival factors and increased levels of dead signals may lead to the malfunction of many cells, including lymphocytes.

Aims & Objective: To explore lymphocytes involvement in wound healing.

Material and Methods: Study participants were divided into three groups: group A, group B and group C (30 participants each). Annexin-V-FITC+CD-3-PE kit were used for the lymphocyte apoptosis estimation in diabetic foot patients by florescent activated cell sorter (FACS).

Results: We find out significantly higher total T cell apoptosis in type 2 diabetes mellitus patients having chronic, non healing diabetic foot ulcer as compared with healthy individuals. CD-3 + Annexin-V-FITC positive lymphocytes were statistically significant in group C (P<0.01) and group B (P<0.001) when compared from group A.

Conclusion: This study suggests the importance of T-lymphocytes in wound healing. From the present study we can suggest diabetic patients to maintain their immune system for the normal wound healing.

Key words: Diabetic foot, Apoptosis, Lymphocyte


 
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How to Cite this Article
Pubmed Style

Arya AK, Garg S, Kumar S, Meena LP, Tripathi K. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. 2013; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132


Web Style

Arya AK, Garg S, Kumar S, Meena LP, Tripathi K. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. http://www.ijmsph.com/?mno=34552 [Access: October 22, 2018]. doi:10.5455/ijmsph.2013.100620132


AMA (American Medical Association) Style

Arya AK, Garg S, Kumar S, Meena LP, Tripathi K. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. 2013; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132



Vancouver/ICMJE Style

Arya AK, Garg S, Kumar S, Meena LP, Tripathi K. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. (2013), [cited October 22, 2018]; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132



Harvard Style

Arya, A. K., Garg, S., Kumar, S., Meena, L. P. & Tripathi, K. (2013) Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132



Turabian Style

Arya, Awadhesh Kumar, Sunny Garg, Santosh Kumar, Lalit P Meena, and Kamlakar Tripathi. 2013. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. International Journal of Medical Science and Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132



Chicago Style

Arya, Awadhesh Kumar, Sunny Garg, Santosh Kumar, Lalit P Meena, and Kamlakar Tripathi. "Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer." International Journal of Medical Science and Public Health 2 (2013), 811-813. doi:10.5455/ijmsph.2013.100620132



MLA (The Modern Language Association) Style

Arya, Awadhesh Kumar, Sunny Garg, Santosh Kumar, Lalit P Meena, and Kamlakar Tripathi. "Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer." International Journal of Medical Science and Public Health 2.4 (2013), 811-813. Print. doi:10.5455/ijmsph.2013.100620132



APA (American Psychological Association) Style

Arya, A. K., Garg, S., Kumar, S., Meena, L. P. & Tripathi, K. (2013) Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. International Journal of Medical Science and Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132





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