E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi

Mishra N K, Kansal S, Mishra J K, Srivastava G N, Rajak B, Sarkar M, Shampa A, Nazmy Abdul Latheef, Maurya A, Rai B K.

Abstract
Background: Tuberculosis (TB) is one of the top ten causes of mortality and the leading cause of a single infectious agent. Unfortunately, India is home to approximately one-fourth of drug-resistant (DR)-TB cases globally. Despite all the developments in TB, the disease is becoming an important threat to public health.

Objective: The present analysis was done to describe the profile and assess and compare the outcome of DR-TB patient admitted in DR-TB ward, Sir Sunderlal Hospital (SSH), Banaras Hindu University (BHU).

Materials and Methods: Retrospective analysis of data from 2013 to 2018 of multi-DR (MDR)-TB patients admitted in DR-TB ward, SSH, Institute of Medical Sciences, BHU and treatment initiated after pre-treatment evaluation was conducted. Patients were referred from nearby nine districts of Uttar Pradesh. After pre-treatment evaluation treatment was initiated at DR-TB center, SSH as well as in their respective district.

Results: A total of 3234 (76.7%) MDR-TB patients out of 4216 MDR-diagnosed patients were initiated on standard treatment which has increased from 74% in 2013. More than 93% of the cases were older than 15 years of age with slightly male predominance. The majority (>96%) of the cases were pulmonary TB. In the present analysis conversion of MDR-TB to extensively DR-TB (XDR-TB) was 7.7%. The treatment success rate for XDR-TB had also significantly improved from 11% in 2015 to 34% in 2017.

Conclusion: Analysis shows 7.7% MDR patients converted into XDR; hence, there is a strong need to explore factors responsible for conversion. 7% of patients were <15 years of age indicating the need for separate pediatric DR-TB ward. 18% of DR-TB patients were defaulters; hence, the reason for it should be sought and addressed. Treatment success rate for MDR-TB has been seen improved from 40% in 2013 to 48% in 2017.

Key words: Clinical; Epidemiological; Multidrug-Resistant; Patients; Treatment Outcome


 
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How to Cite this Article
Pubmed Style

K MN, S K, K MJ, N SG, B R, M S, A S, Latheef NA, A M, K RB. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. Int J Med Sci Public Health. 2019; 8(5): 395-400. doi:10.5455/ijmsph.2019.0305326032019


Web Style

K MN, S K, K MJ, N SG, B R, M S, A S, Latheef NA, A M, K RB. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. http://www.ijmsph.com/?mno=35477 [Access: August 20, 2019]. doi:10.5455/ijmsph.2019.0305326032019


AMA (American Medical Association) Style

K MN, S K, K MJ, N SG, B R, M S, A S, Latheef NA, A M, K RB. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. Int J Med Sci Public Health. 2019; 8(5): 395-400. doi:10.5455/ijmsph.2019.0305326032019



Vancouver/ICMJE Style

K MN, S K, K MJ, N SG, B R, M S, A S, Latheef NA, A M, K RB. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. Int J Med Sci Public Health. (2019), [cited August 20, 2019]; 8(5): 395-400. doi:10.5455/ijmsph.2019.0305326032019



Harvard Style

K, M. N., S, . K., K, . M. J., N, . S. G., B, . R., M, . S., A, . S., Latheef, . N. A., A, . M. & K, . R. B. (2019) Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. Int J Med Sci Public Health, 8 (5), 395-400. doi:10.5455/ijmsph.2019.0305326032019



Turabian Style

K, Mishra N, Kansal S, Mishra J K, Srivastava G N, Rajak B, Sarkar M, Shampa A, Nazmy Abdul Latheef, Maurya A, and Rai B K. 2019. Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. International Journal of Medical Science and Public Health, 8 (5), 395-400. doi:10.5455/ijmsph.2019.0305326032019



Chicago Style

K, Mishra N, Kansal S, Mishra J K, Srivastava G N, Rajak B, Sarkar M, Shampa A, Nazmy Abdul Latheef, Maurya A, and Rai B K. "Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi." International Journal of Medical Science and Public Health 8 (2019), 395-400. doi:10.5455/ijmsph.2019.0305326032019



MLA (The Modern Language Association) Style

K, Mishra N, Kansal S, Mishra J K, Srivastava G N, Rajak B, Sarkar M, Shampa A, Nazmy Abdul Latheef, Maurya A, and Rai B K. "Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi." International Journal of Medical Science and Public Health 8.5 (2019), 395-400. Print. doi:10.5455/ijmsph.2019.0305326032019



APA (American Psychological Association) Style

K, M. N., S, . K., K, . M. J., N, . S. G., B, . R., M, . S., A, . S., Latheef, . N. A., A, . M. & K, . R. B. (2019) Clinico-epidemiological profile and treatment outcome of drug-resistant tuberculosis patients admitted to drug-resistant-tuberculosis center in a tertiary care hospital in Varanasi. International Journal of Medical Science and Public Health, 8 (5), 395-400. doi:10.5455/ijmsph.2019.0305326032019





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