E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala.

Abstract
Background: With all the modern needs of contraception rising on one side, infertility is still a major challenge to the gynaecological practitioners on other hand. Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility, being found in ∼75% of cases. PCOS now proves to be a significant factor in female infertility with prevalence of 0.6 to 3.4% in infertile couples. With improving laboratory facilities, sonography and with routine laparoscopic evaluation of infertility, PCOS has shown a remarkable increase of incidence in recent years.

Aims & Objective: The diagnosis of PCOS by ultrasonography & investigations like LH, FSH, Prolactin and or Laparoscopy. The evaluation of treatment options like clomiphene citrate, metformin and laparoscopic ovarian drilling.

Material and Methods: This is a study of 100 cases of infertility with polycystic ovarian syndrome and its pregnancy outcome. In this study from May 2011 to April 2013,100 cases of Infertility with PCOS were studied at the tertiary care center. Hormonal assay, Ultrasound and laparoscopy were used for diagnosis. Clomiphene citrate, metformin and laparoscopic ovarian drilling were used as treatment modalities.

Results: In our study 58% patients were in the age group of 21-25 years and 100% patients complained of infertility among which 60% were of primary type. LH:FSH ratio was more than 1.6 in nearly 82% patients. Among all treatment modalities conception rate with Clomiphene citrate was 40%, with metformin it was 20% and with laparoscopic ovarian drilling followed by C/C it was 65%.

Conclusion: PCOS is emerging disease of the new generation found more in young adults being the leading cause of infertility. Apart from diet and exercise changes in lifestyle modification treatment is required in most patients with good conception rate with C/C and laparoscopic ovarian drilling.

Key words: Infertility, polycystic ovarian syndrome, metformin, clomiphene citrate, laparoscopic ovarian drilling.


 
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REFERENCES
1. Homburg R. The management of infertility associated with PCOS. Reprod Biol Endocrinol. 2003;1:109. [DOI via Crossref]   
2. Shannon M, Wang Y. Polycystic ovary syndrome: a common but often unrecognized condition. J Midwifery Womens Health. 2012;57(3):221-30. [DOI via Crossref]   
3. Goudas VT, Dumesic DA. Polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1997;26:893-912. [DOI via Crossref]   
4. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Fertil Steril. 2004;81(1):19-25. [DOI via Crossref]   
5. Azziz R. Diagnostic criteria for PCOS a reappraisal. Fertil Steril. 2000;83:1343-46. [DOI via Crossref]   
6. Atiomo WU, Pearson S, Shaw S, Dubbins P. Ultrasound criteria in the diagnosis of PCOS. Ultrasound Med Biol 2000;19:41-47.
7. Eijkemans MJ, Imani B, Mulders AG, Habbema JD, Fauser BC. High singleton live birth rate following classical ovulation induction in normogonadotrophic anovulatory infertility (WHO 2) Hum Reprod. 2003;18:2357-2362. [DOI via Crossref]   
8. Thatcher SS, Jackson EM. Pregnancy outcome in infertile patients with PCOS who were treated with metformin. Fertil Steril. 2006;85:1002-9. [DOI via Crossref]   
9. Barberi RL. Metformin for the treatment of polycystic ovary syndrome. Obstet Gynecol. 2003;101(4):785-93. [DOI via Crossref]   
10. Panidis D, Tziomalos K, Chatzis P, Papadakis E, Delkos D, Tsourdi EA, et al. Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the PCOS. Eur J Endocrinol. 2013;168:145-52. [DOI via Crossref]   
11. Oh JY, Sung YA, Lee HJ. Clinical implications of menstrual cycle length in oligomenorrhoeic young woman. Clin Enocrinol. 2013;11:44-48.
12. Panidis D, Tziomalos K, Papadakis E, Vosnakis C, Chatzis P. Lifestyle intervention and anti-obesity therapies in the polycystic ovary syndrome: impact on metabolism and fertility. Endocrine. 2013;10:22-25.
13. Roe AH, Dokras A. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Rev Obstet Gynecol. 2011; 4(2): 45-51.
14. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. The consensus on infertility treatment related with PCOS. Human Reproduct. 2008;23:462-77.
15. Kar S. Clomiphene citrate or latrozole as first line ovulation induction drug in infertile patients with PCOS. J Hum Reprod Sci. 2012;5:262-5. [DOI via Crossref]   
16. Vause TD, Cheung AP, Sierra S, Claman P, Graham J, Guillemin JA, et al. Ovulation induction in PCOS. J Obstet Gynaecol Can. 2010;32(5):495-502.
17. Vandermolen DT, Ratts VS, Evans WS, Stovall DW, Kauma SW, Nestler JE. Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril. 2001;75:310-15. [DOI via Crossref]   
18. Poujade O, Gervaise A. Surgical management of infertility due to PCOS after failure of medical management. Eur J Obstet Gynaecol Reprod Biol. 2011;158;242-7. [DOI via Crossref]   
19. Palomba S, Falbo A, Battista L, Russo T, Venturella R, Tolino A, et al. Laproscopic ovarian diathermy vs clomiphene citrate plus metformin as second line strategy for infertile anovulatory patients with PCOS:a randomised controlled trial. Am J Obstet Gynaecol. 2010;202:577. [DOI via Crossref]   
20. Farquhar C, Brown J, Marjoribanks J. Laparoscopic drilling by diathermy or laser for ovulation induction in PCOS. Cochrane Database Syst Rev. 2007;3:.7-10.

How to Cite this Article
Pubmed Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. Int J Med Sci Public Health. 2013; 2(4): 1041-1045. doi:10.5455/ijmsph.2013.260820131


Web Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. http://www.ijmsph.com/?mno=43014 [Access: November 21, 2018]. doi:10.5455/ijmsph.2013.260820131


AMA (American Medical Association) Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. Int J Med Sci Public Health. 2013; 2(4): 1041-1045. doi:10.5455/ijmsph.2013.260820131



Vancouver/ICMJE Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. Int J Med Sci Public Health. (2013), [cited November 21, 2018]; 2(4): 1041-1045. doi:10.5455/ijmsph.2013.260820131



Harvard Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala (2013) Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. Int J Med Sci Public Health, 2 (4), 1041-1045. doi:10.5455/ijmsph.2013.260820131



Turabian Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. 2013. Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. International Journal of Medical Science and Public Health, 2 (4), 1041-1045. doi:10.5455/ijmsph.2013.260820131



Chicago Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. "Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome." International Journal of Medical Science and Public Health 2 (2013), 1041-1045. doi:10.5455/ijmsph.2013.260820131



MLA (The Modern Language Association) Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala. "Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome." International Journal of Medical Science and Public Health 2.4 (2013), 1041-1045. Print. doi:10.5455/ijmsph.2013.260820131



APA (American Psychological Association) Style

Vrunda Dhagat, Parul Shah, Rajal Thakar, Kruti Deliwala (2013) Study of 100 cases of Infertility in Polycystic ovarian syndrome and its management outcome. International Journal of Medical Science and Public Health, 2 (4), 1041-1045. doi:10.5455/ijmsph.2013.260820131





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