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Case Report

Int J Med Sci Public Health. 2014; 3(3): 372-374

doi: 10.5455/ijmsph.2013.251220131

Sugammadex associate persistant bradycardia

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu.

Cited by (7)

Abstract
Sugammadex is a safe selective relaxant binding agent, composed of modified cyclodextrin molecules. It especially has a selectivity for neuromuscular blocking agents (NMBAs) of steroid composition, such as rocuronium and vecuronium. In this paper, we present a case where intravenous (iv) sugammadex has been applied and subsequently persistent bradycardia has developed. A 56-year-old male patient (weight 77 kg, height 163 cm) was scheduled for ureterorenoscopy because of a stone in the upper part of ureter. Preoperative examination showed possible difficult intubation (mallampati 3). There are no known heart diseases and no history of any drug use. The electrocardiography was in normal sinus rhythm, and the blood biochemistry was normal. (WBC: 8.47 K/mm3; Hb: 14.3 g/dL; Na: 135 mEq/L; K: 3.9 mEq/L; BUN: 41 mg/dL; Creatin: 0.69 mg/dL).When the operation ended, We monitored neuromuscular block level with a neuromuscular monitoring device (TOF- Watch S). At the end of the operation, 200 mg sugammadex (Bridion 200 mg/2 mL, MSD) was administered to the patient through iv injection. Approximately 2 minutes following the administration, the patient developed sinusoidal bradycardia (pulse 35 beats/min). We believe that cardiac side effects may be observed following sugammadex administration and that atropine-resistant bradycardia may also develop.

Key words: Sugammadex; Bradycardia; Case Report

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This Article Cited By the following articles

Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient A & A Practice 2019; 12(1): 22.	1

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Sugammadex-induced bradycardia and asystole: how great is the risk? British Journal of Anaesthesia 2018; 121(1): 8.	3

Bradicardia grave e assistolia associadas ao sugamadex: relato de caso clínico Brazilian Journal of Anesthesiology 2018; (): .	4

Bradycardia in a Pediatric Heart Transplant Recipient: Is It the Sugammadex? The Journal of Pediatric Pharmacology and Therapeutics 2017; 22(5): 378.	5

Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials Journal of Clinical Anesthesia 2016; 35(): 1.	6

Sugammadex: watch out for new side effects Korean J Anesthesiol 2016; 69(5): 427.	7

How to Cite this Article

Pubmed Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. Sugammadex associate persistant bradycardia. Int J Med Sci Public Health. 2014; 3(3): 372-374. doi:10.5455/ijmsph.2013.251220131

Web Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. Sugammadex associate persistant bradycardia. http://www.ijmsph.com/?mno=48110 [Access: January 20, 2019]. doi:10.5455/ijmsph.2013.251220131

AMA (American Medical Association) Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. Sugammadex associate persistant bradycardia. Int J Med Sci Public Health. 2014; 3(3): 372-374. doi:10.5455/ijmsph.2013.251220131

Vancouver/ICMJE Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. Sugammadex associate persistant bradycardia. Int J Med Sci Public Health. (2014), [cited January 20, 2019]; 3(3): 372-374. doi:10.5455/ijmsph.2013.251220131

Harvard Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu (2014) Sugammadex associate persistant bradycardia. Int J Med Sci Public Health, 3 (3), 372-374. doi:10.5455/ijmsph.2013.251220131

Turabian Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. 2014. Sugammadex associate persistant bradycardia. International Journal of Medical Science and Public Health, 3 (3), 372-374. doi:10.5455/ijmsph.2013.251220131

Chicago Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. "Sugammadex associate persistant bradycardia." International Journal of Medical Science and Public Health 3 (2014), 372-374. doi:10.5455/ijmsph.2013.251220131

MLA (The Modern Language Association) Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu. "Sugammadex associate persistant bradycardia." International Journal of Medical Science and Public Health 3.3 (2014), 372-374. Print. doi:10.5455/ijmsph.2013.251220131

APA (American Psychological Association) Style

Murat Bilgi, Abdullah Demirhan, Akcan Akkaya, Umit Yasar Tekelioglu, Hasan Kocoglu (2014) Sugammadex associate persistant bradycardia. International Journal of Medical Science and Public Health, 3 (3), 372-374. doi:10.5455/ijmsph.2013.251220131



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