E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center

Anjan Bera, Shatarupa Dutta, Linkon Biswas, Aparajita Sadhya.

Abstract
Background: Lung cancer is the most common cancer and leading cause cancer-related death in worldwide and also in India. Around 42% of these patients have adenocarcinoma. Most of these patients presented in locally advanced stage or metastatic disease. There is no significant difference in effectiveness among different chemotherapy regimens with median survival of 8 months only. Hence, additional treatment option including newer monoclonal antibodies is needed to improve tumor control and survival. Vascular endothelial growth factor (VEGF) is critical determinant of tumor angiogenesis, a process that is necessary component of tumor growth, invasion, and metastasis. Bevacizumab (Bev), a humanized monoclonal antibody (IgG1) targeting VEGF, effective in colorectal cancer, renal cell carcinoma, glioblastoma multiforme, and non-small cell lung cancer and approved for clinical use since 2004.

Objectives: The aim of our study is feasibility of the combination of Bev with paclitaxel and carboplatin in locally advanced (Stage IIIB) metastatic adenocarcinoma of lung in our institute, N.R.S. Medical College and Hospital, Kolkata.

Materials and Methods: Between February 2015 and December 2018, ninety-eight previously untreated patients with locally advanced metastatic (Stages IIIB and IV) adenocarcinoma of lung treated with Bev with paclitaxel and carboplatin. Paclitaxel at a dose of 175 mg/m2, carboplatin at an AUC 6 mg/ml/min, and Bev at a dose of 15 mg/kg given on the 1st day of chemotherapy. Chemotherapy administered every 3 weeks up to 6 cycles with maintenance Bev until disease progression or unacceptable toxicity whichever is earlier. Patients ECOG 2 or more, brain metastasis, squamous cell histology, and hemoptysis were not included in the study.

Results: The Median overall survival (OS), progression free survival (PFS) were 9.4 and 5.2 months, respectively. Anemia (19%) and neutropenia (16 %) are most common toxicity.

Conclusion: Bev with paclitaxel and carboplatin in selected patients with adenocarcinoma of lung is safe and confers survival benefit with acceptable toxicity.

Key words: Bevacizumab; Paclitaxel; Carboplatin; Adenocarcinoma; Toxicity


 
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How to Cite this Article
Pubmed Style

Bera A, Dutta S, Biswas L, Sadhya A. Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. Int J Med Sci Public Health. 2019; 8(10): 877-880. doi:10.5455/ijmsph.2019.0823026082019


Web Style

Bera A, Dutta S, Biswas L, Sadhya A. Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. http://www.ijmsph.com/?mno=61772 [Access: October 21, 2019]. doi:10.5455/ijmsph.2019.0823026082019


AMA (American Medical Association) Style

Bera A, Dutta S, Biswas L, Sadhya A. Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. Int J Med Sci Public Health. 2019; 8(10): 877-880. doi:10.5455/ijmsph.2019.0823026082019



Vancouver/ICMJE Style

Bera A, Dutta S, Biswas L, Sadhya A. Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. Int J Med Sci Public Health. (2019), [cited October 21, 2019]; 8(10): 877-880. doi:10.5455/ijmsph.2019.0823026082019



Harvard Style

Bera, A., Dutta, . S., Biswas, . L. & Sadhya, . A. (2019) Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. Int J Med Sci Public Health, 8 (10), 877-880. doi:10.5455/ijmsph.2019.0823026082019



Turabian Style

Bera, Anjan, Shatarupa Dutta, Linkon Biswas, and Aparajita Sadhya. 2019. Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. International Journal of Medical Science and Public Health, 8 (10), 877-880. doi:10.5455/ijmsph.2019.0823026082019



Chicago Style

Bera, Anjan, Shatarupa Dutta, Linkon Biswas, and Aparajita Sadhya. "Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center." International Journal of Medical Science and Public Health 8 (2019), 877-880. doi:10.5455/ijmsph.2019.0823026082019



MLA (The Modern Language Association) Style

Bera, Anjan, Shatarupa Dutta, Linkon Biswas, and Aparajita Sadhya. "Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center." International Journal of Medical Science and Public Health 8.10 (2019), 877-880. Print. doi:10.5455/ijmsph.2019.0823026082019



APA (American Psychological Association) Style

Bera, A., Dutta, . S., Biswas, . L. & Sadhya, . A. (2019) Bevacizumab with paclitaxel and carboplatin for locally advanced (Stage IIIB) metastatic adenocarcinoma of lung: A feasibility study from tertiary care center. International Journal of Medical Science and Public Health, 8 (10), 877-880. doi:10.5455/ijmsph.2019.0823026082019





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