A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study

Sankha Subhra Chaudhari | Asim Kumar Dey | Subhasis Jana| Mousumi Bandyopadhyay

2020, Vol: 9, Issue: 6

9 / 6Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Research

Int J Med Sci Public Health. 2020; 9(1): 39-43

doi: 10.5455/ijmsph.2020.1029929102019

A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study

Sankha Subhra Chaudhari, Asim Kumar Dey, Subhasis Jana, Mousumi Bandyopadhyay.

Abstract
Background: Neurodegeneration of retina (retinal diabetic neuropathy) is the earlier sign of diabetes mellitus before the appearance of any vascular sign of diabetic retinopathy. Hence, through neurodegenerative changes, we can diagnose and monitor the early neuronal damage of the retina.

Objectives: The objective of the study were to establish whether the retinal neurodegeneration is earlier than vasculopathic changes in patients with diabetes and their relationship with the duration of diabetes.

Materials and Methods: A total of 180 diabetic patients and 164 healthy controls were collected from a rural-based tertiary care hospital in West Bengal for this cross-sectional study. All have gone through proper history taking, comprehensive ocular examinations and spectral-domain optical coherence tomography imaging to detect the thickness of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL).

Results: Our study showed that the RNFL thickness of the right and left eyes for the cases was 37.62 Î¼m and 37.68 Î¼m, respectively, and that for controls were 39.68 Î¼m and 39.70 Î¼m, respectively. The GCL thickness of the right and left eyes was 32.63 Î¼m and 32.43 Î¼m, respectively, in cases and that for controls were 33.73 Î¼m and 33.87 Î¼m, respectively. In respect of the duration of diabetes, mean RNFL thickness of the right and left eyes for <1 year, 1–2 years, and >2 years was 40.20 Î¼m and 40.03 Î¼m; 38.17 Î¼m and 38.31 Î¼m; and 35.48 Î¼m and 35.69 Î¼m, respectively. Mean GCL thickness of the right and left eyes for <1 year, 1–2 years, and >2 years was 34.25 Î¼m and 33.72 Î¼m; 31.98 Î¼m and 31.44 Î¼m; and 30.82 Î¼m and 31.35 Î¼m, respectively. The data were analyzed by appropriate statistical methods.

Conclusion: This study showed that thinning of RNFL and GCL occurred in diabetes before the appearance of microaneurysm.

Key words: Diabetic Retinopathy; Retinal Nerve Fiber Layer; Ganglion Cell Layer; Retinal Neurodegeneration; Optical Coherence Tomography

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Sankha Subhra Chaudhari Articles by Asim Kumar Dey Articles by Subhasis Jana Articles by Mousumi Bandyopadhyay
	on Google
	on Google Scholar
	Article Statistics
	Viewed: 570 Downloaded: 59

How to Cite this Article

Pubmed Style

SSC, AKD, Jana S, Bandyopadhyay M. A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. Int J Med Sci Public Health. 2020; 9(1): 39-43. doi:10.5455/ijmsph.2020.1029929102019

Web Style

SSC, AKD, Jana S, Bandyopadhyay M. A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. http://www.ijmsph.com/?mno=69722 [Access: February 16, 2020]. doi:10.5455/ijmsph.2020.1029929102019

AMA (American Medical Association) Style

SSC, AKD, Jana S, Bandyopadhyay M. A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. Int J Med Sci Public Health. 2020; 9(1): 39-43. doi:10.5455/ijmsph.2020.1029929102019

Vancouver/ICMJE Style

SSC, AKD, Jana S, Bandyopadhyay M. A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. Int J Med Sci Public Health. (2020), [cited February 16, 2020]; 9(1): 39-43. doi:10.5455/ijmsph.2020.1029929102019

Harvard Style

, S. S. C., , . A. K. D., Jana, . S. & Bandyopadhyay, . M. (2020) A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. Int J Med Sci Public Health, 9 (1), 39-43. doi:10.5455/ijmsph.2020.1029929102019

Turabian Style

, Sankha Subhra Chaudhari, Asim Kumar Dey, Subhasis Jana, and Mousumi Bandyopadhyay. 2020. A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. International Journal of Medical Science and Public Health, 9 (1), 39-43. doi:10.5455/ijmsph.2020.1029929102019

Chicago Style

, Sankha Subhra Chaudhari, Asim Kumar Dey, Subhasis Jana, and Mousumi Bandyopadhyay. "A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study." International Journal of Medical Science and Public Health 9 (2020), 39-43. doi:10.5455/ijmsph.2020.1029929102019

MLA (The Modern Language Association) Style

, Sankha Subhra Chaudhari, Asim Kumar Dey, Subhasis Jana, and Mousumi Bandyopadhyay. "A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study." International Journal of Medical Science and Public Health 9.1 (2020), 39-43. Print. doi:10.5455/ijmsph.2020.1029929102019

APA (American Psychological Association) Style

, S. S. C., , . A. K. D., Jana, . S. & Bandyopadhyay, . M. (2020) A study of retinal neurodegeneration using optical coherence tomography in type 2 diabetes mellitus patients without retinopathy: A cross-sectional study. International Journal of Medical Science and Public Health, 9 (1), 39-43. doi:10.5455/ijmsph.2020.1029929102019

Authors retains the copyright of the manuscript/s published by them in this journal.

Copyright © 2020 International Journal of Medical Science and Public Health All Rights Reserved. Subject to change without notice from or liability to International Journal of Medical Science and Public Health. For best results, please use Internet Explorer or Google Chrome	Contact Information Publisher publisherijmsph@gmail.com Editorial query editorijmsph1@gmail.com MOB - 8780040272

Contact Information

How to cite this article