E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study

Tapas Kumar Das, Kaustav Chatterjee, Sunita Das, Linkon Biswas.

Abstract
Background: External beam radiotherapy with concurrent chemotherapy has become the mainstay of treatment for locally advanced head and neck cancers.

Objective: The objective of this study was to compare paclitaxel to cisplatin as an agent for concurrent chemoradiation in locally advanced squamous cell carcinoma of head neck region in terms of toxicities and response to treatment.

Materials and Methods: Biopsy-proven Stage III and Stage IVA head and neck squamous cell cancer patients were included in the study. The study arm patients received concurrent dose of paclitaxel 20 mg/m2 I/V 1 h infusion 4 h before radiation, repeated weekly for 6 cycles. Patients in the control arm received concurrent dose of cisplatin 30 mg/m2 I/V 1 h infusion 4 h before radiation, repeated weekly for 6 cycles. Patients of both arms received a total dose of 66 Gy external beam radiation, 200 cGy/day, 5 fractions in a week in 6.5 weeks treated on a Theratron 780E Cobalt-60 teletherapy unit.

Results: Acute Grades III and IV renal toxicity and nausea were reported significantly more number of cases in cisplatin arm in comparison to paclitaxel arm. There was no statistically significant difference observed in the groups in terms of treatment response and failure pattern (Ο‡2 = 3.63, df = 1, level of significance 0.05). On follow-up, up to 6 months, 51.85% of cases are disease free in the control arm and 50.66% of cases in the study arm.

Conclusion: Low-dose weekly paclitaxel concurrent with external beam radiation therapy given in conventional fractionation is comparable to concurrent cisplatin in locally advanced head and neck squamous cell carcinoma in terms of efficacy. There is lower incidence of severe renal toxicity and vomiting with concurrent paclitaxel than with cisplatin.

Key words: External Beam Radiotherapy; Concurrent Chemotherapy; Head and Neck Cancer


 
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How to Cite this Article
Pubmed Style

Das TK, Chatterjee K, Das S, Biswas L. Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. Int J Med Sci Public Health. 2020; 9(1): 97-100. doi:10.5455/ijmsph.2020.1133302122019


Web Style

Das TK, Chatterjee K, Das S, Biswas L. Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. http://www.ijmsph.com/?mno=75521 [Access: January 29, 2020]. doi:10.5455/ijmsph.2020.1133302122019


AMA (American Medical Association) Style

Das TK, Chatterjee K, Das S, Biswas L. Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. Int J Med Sci Public Health. 2020; 9(1): 97-100. doi:10.5455/ijmsph.2020.1133302122019



Vancouver/ICMJE Style

Das TK, Chatterjee K, Das S, Biswas L. Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. Int J Med Sci Public Health. (2020), [cited January 29, 2020]; 9(1): 97-100. doi:10.5455/ijmsph.2020.1133302122019



Harvard Style

Das, T. K., Chatterjee, . K., Das, . S. & Biswas, . L. (2020) Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. Int J Med Sci Public Health, 9 (1), 97-100. doi:10.5455/ijmsph.2020.1133302122019



Turabian Style

Das, Tapas Kumar, Kaustav Chatterjee, Sunita Das, and Linkon Biswas. 2020. Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. International Journal of Medical Science and Public Health, 9 (1), 97-100. doi:10.5455/ijmsph.2020.1133302122019



Chicago Style

Das, Tapas Kumar, Kaustav Chatterjee, Sunita Das, and Linkon Biswas. "Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study." International Journal of Medical Science and Public Health 9 (2020), 97-100. doi:10.5455/ijmsph.2020.1133302122019



MLA (The Modern Language Association) Style

Das, Tapas Kumar, Kaustav Chatterjee, Sunita Das, and Linkon Biswas. "Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study." International Journal of Medical Science and Public Health 9.1 (2020), 97-100. Print. doi:10.5455/ijmsph.2020.1133302122019



APA (American Psychological Association) Style

Das, T. K., Chatterjee, . K., Das, . S. & Biswas, . L. (2020) Concurrent chemoradiation with paclitaxel versus cisplatin in locally advanced head and neck cancer patients – A prospective comparative study. International Journal of Medical Science and Public Health, 9 (1), 97-100. doi:10.5455/ijmsph.2020.1133302122019





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