E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin

Tapas Kumar Das, Kaustav Chatterjee.

Abstract
Background: Rechallenge of a platinum-based chemotherapy is the most common approach for a recurrent platinumsensitive epithelial carcinoma ovary. However, this carries a substantial risk of cumulative neurotoxicity.

Objectives: In the present study, we tried to compare the efficacy and toxicities of gemcitabine pegylated liposomal doxorubicin combination regimen to rechallenge of paclitaxel-carboplatin in this setting.

Materials and Methods: A total of 30 patients were included in the study. The patients were randomized into two groups each containing 15 patients. The study group received injection gemcitabine at the dose of 1 g/m2 injection intravenously on day 1 and day 8 and liposomal doxorubicin 30 mg/m2 on day 1 in a 3 weekly cycle up to a total of six cycles in absence of disease progression or unacceptable toxicities. The control group patients were treated with injection paclitaxel at a dose of 175 mg/m2 I/V infusion and injection carboplatin at a dose considering area under the curve 6 in a 3 weekly for six cycles.

Results: In the study arm, out of 14 patients, 4 (28.57%) patients had complete response, 6 (42.85%) had partial response, 3 (21.42%) had stable disease, and 1 (7.14%) showed disease progression. In the control arm, 6 (40%) patients out of 15 showed complete response, and 4 (26.66%) partial response. Disease progression was noted in 1 (6.66%) patient. There was less incidence of neurotoxicity compared to the control arm.

Conclusion: Chemotherapy with a combination of gemcitabine and pegylated liposomal doxorubicin shows equivalent efficacy in platinum-sensitive recurrent ovarian cancer when compared to rechallenge of platinum-based chemotherapy. The regimen has an acceptable toxicity profile with lesser incidence of neuropathy than rechallenge of paclitaxel-carboplatin combination.

Key words: Recurrent Ovarian Cancer; Rechallenge; Platinum Sensitive; Response; Toxicity


 
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How to Cite this Article
Pubmed Style

Das TK, Chatterjee K. A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020


Web Style

Das TK, Chatterjee K. A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. http://www.ijmsph.com/?mno=78809 [Access: February 16, 2020]. doi:10.5455/ijmsph.2020.12348201930012020


AMA (American Medical Association) Style

Das TK, Chatterjee K. A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020



Vancouver/ICMJE Style

Das TK, Chatterjee K. A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020



Harvard Style

Das, T. K. & Chatterjee, . K. (2020) A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020



Turabian Style

Das, Tapas Kumar, and Kaustav Chatterjee. 2020. A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020



Chicago Style

Das, Tapas Kumar, and Kaustav Chatterjee. "A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin." doi:10.5455/ijmsph.2020.12348201930012020



MLA (The Modern Language Association) Style

Das, Tapas Kumar, and Kaustav Chatterjee. "A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin." doi:10.5455/ijmsph.2020.12348201930012020



APA (American Psychological Association) Style

Das, T. K. & Chatterjee, . K. (2020) A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin. doi:10.5455/ijmsph.2020.12348201930012020





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