E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study

Kalpita S Korabu, Kailas D Datkhile, Madhavi N Patil, Pratik P Durgawale, Shreepad A Joshi, Satish V Kakade.

Abstract
Background: Maharashtrian population is at the risk of cervical cancer (CC) and is not subjected to investigate the cancer susceptibility in association with genetic determinants.

Objectives: This study was aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in DNA repair gene xeroderma pigmentosum complementation group D (XPD) with CC risk from rural Maharashtra.

Materials and Methods: We used polymerase chain reaction and-restriction fragment length polymorphism to analyze SNPs in XPD gene from 350 patients with CC and 400 age and sex-matched disease-free controls.

Results: The results indicated no significant difference in the genotype distribution between CC patients and controls for the XPD gene at codon 156 of exon 6 and codon 751 of exon 23, but the results showed that allele frequencies of XPD Asn 312 of codon 312 of exon 10 (odds ratio = 0.31; 95% confidence intervals = [0.16–0.63]; P = <0.001) genotype showed negative association with CC risk.

Conclusion: This study indicated the role of XPD (cd312) in modifying genetic susceptibility of an individual to CC in Maharashtrian patients.

Key words: Cervical Cancer; Genetic Polymorphism; Xeroderma Pigmentosum Complementation Group D; Polymerase Chain Reaction and Restriction Fragment Length Polymorphism


 
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How to Cite this Article
Pubmed Style

Korabu KS, Datkhile KD, Patil MN, Durgawale PP, Joshi SA, Kakade SV. Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. Int J Med Sci Public Health. 2019; 8(1): 46-52. doi:10.5455/ijmsph.2019.0928217102018


Web Style

Korabu KS, Datkhile KD, Patil MN, Durgawale PP, Joshi SA, Kakade SV. Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. http://www.ijmsph.com/?mno=9616 [Access: June 24, 2019]. doi:10.5455/ijmsph.2019.0928217102018


AMA (American Medical Association) Style

Korabu KS, Datkhile KD, Patil MN, Durgawale PP, Joshi SA, Kakade SV. Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. Int J Med Sci Public Health. 2019; 8(1): 46-52. doi:10.5455/ijmsph.2019.0928217102018



Vancouver/ICMJE Style

Korabu KS, Datkhile KD, Patil MN, Durgawale PP, Joshi SA, Kakade SV. Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. Int J Med Sci Public Health. (2019), [cited June 24, 2019]; 8(1): 46-52. doi:10.5455/ijmsph.2019.0928217102018



Harvard Style

Korabu, K. S., Datkhile, . K. D., Patil, . M. N., Durgawale, . P. P., Joshi, . S. A. & Kakade, . S. V. (2019) Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. Int J Med Sci Public Health, 8 (1), 46-52. doi:10.5455/ijmsph.2019.0928217102018



Turabian Style

Korabu, Kalpita S, Kailas D Datkhile, Madhavi N Patil, Pratik P Durgawale, Shreepad A Joshi, and Satish V Kakade. 2019. Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. International Journal of Medical Science and Public Health, 8 (1), 46-52. doi:10.5455/ijmsph.2019.0928217102018



Chicago Style

Korabu, Kalpita S, Kailas D Datkhile, Madhavi N Patil, Pratik P Durgawale, Shreepad A Joshi, and Satish V Kakade. "Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study." International Journal of Medical Science and Public Health 8 (2019), 46-52. doi:10.5455/ijmsph.2019.0928217102018



MLA (The Modern Language Association) Style

Korabu, Kalpita S, Kailas D Datkhile, Madhavi N Patil, Pratik P Durgawale, Shreepad A Joshi, and Satish V Kakade. "Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study." International Journal of Medical Science and Public Health 8.1 (2019), 46-52. Print. doi:10.5455/ijmsph.2019.0928217102018



APA (American Psychological Association) Style

Korabu, K. S., Datkhile, . K. D., Patil, . M. N., Durgawale, . P. P., Joshi, . S. A. & Kakade, . S. V. (2019) Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study. International Journal of Medical Science and Public Health, 8 (1), 46-52. doi:10.5455/ijmsph.2019.0928217102018





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