Association between serum ferritin and thyroid hormone profile in hypothyroidism

Ashuma Sachdeva; Veena Singh; Isha Malik; Prasanta Saha Roy; Himanshu Madaan; Rajesh Nair

doi:10.5455/ijmsph.2015.24012015174

2021, Vol: 10, Issue: 2

10 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Short Communication

Int J Med Sci Public Health. 2015; 4(6): 863-865

doi: 10.5455/ijmsph.2015.24012015174

Association between serum ferritin and thyroid hormone profile in hypothyroidism

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair.

Cited by (1)

Abstract
Background: Ferritin is an iron storage protein found in almost all of the body tissues. Serum ferritin levels also have been reported to be altered in patients with thyroid disease. Thus, changes in the serum concentrations of ferritin reflect thyroid function.

Objective: For the synthesis of thyroid hormones, thyroperoxidase requires iron. It has been suggested that there is an association between thyroid profile and ferritin levels, which is the storage protein for iron in the body. This study was undertaken to assess ferritin levels in hypothyroid patients.

Materials and Methods: Ferritin levels were estimated in 50 newly diagnosed patients of hypothyroidism using chemiluminescence technique (ADVIA Centaur CP). Total T3 and T4 levels were estimated using radioimmunoassay. Free T3, T4, and thyroid-stimulating hormone (TSH) levels were estimated using chemiluminescence. These were then compared with age- and sex-matched healthy controls. Results were correlated statistically.

Results: Serum ferritin levels were found to be significantly reduced in patients with hypothyroidism compared to normal subjects (p < 0.001).

Conclusion: Hypothyroidism is associated with low serum ferritin levels. The estimation of serum ferritin may help in understanding the etiopathogenesis, diagnosis, and monitoring of hypothyroid patients.

Key words: Ferritin, hypothyroidism, thyroid

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Ashuma Sachdeva Articles by Veena Singh Articles by Isha Malik Articles by Prasanta Saha Roy Articles by Himanshu Madaan Articles by Rajesh Nair
	on Google
	on Google Scholar

REFERENCES

1. Takamatsu J, Majima M, Miki K, Kuma K, Mozai T. Serum ferritin as a marker of thyroid hormone action on peripheral tissues. J Clin Endocrinol Metabol 1985;61(4):672-6. [DOI via Crossref] [Pubmed]

2. Pitt-Rivers RV, Trotter WR, Wolff EC, Wolff J. The Thyroid Gland. London: Butterworths, 1964. pp. 1, 237-282.

3. Akhter S, Nahar ZU, Parvin S, Alam A, Sharmin S, Arslan MI. Thyroid status in patients with low serum ferritin level. Bangladesh J Med Biochem 2012;5(1):5-11.

4. Granner DK. The diversity of the endocrine system. In: HarperÃ‚Â’s llustrated Biochemistry, RK Murray, DK Granner, PA Mayes, VW Rodwell (Eds.), 26th edn. USA: McGraw-Hill, 2003. pp. 434-55.

5. Klausner RD, Rouault TA, Harford, JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 1993;72(1):19-28. [DOI via Crossref]

6. Goossen B, Hentze MW. Position is the critical determinant for function of iron-responsive elements as translational regulators. Mol Cell Biol 1992;12:1959-66. [Pubmed] [PMC Free Fulltext]

7. Mullner EW, Kuhn LC. A stem-loop in the 3Ã‚Â’ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 1988;53(5):815-25. [DOI via Crossref]

8. Tang CK, Chin J, Harford JB, Klausner RD, Rouault TA. Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation. J Biol Chem 1992;267(34):24466-70. [Pubmed]

This Article Cited By the following articles

The Influence of Iron Depletion and Chronic Energy Deficiency on the Risk of Hypothyroidism in Pregnant Women Living in Iodine Deficiency Disorders Endemic Areas in Badegan Ponorogo District East Java, Indonesia J Nutr Sci Vitaminol 2020; 66(Supplement): S456.	1

How to Cite this Article

Pubmed Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. Association between serum ferritin and thyroid hormone profile in hypothyroidism. Int J Med Sci Public Health. 2015; 4(6): 863-865. doi:10.5455/ijmsph.2015.24012015174

Web Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. Association between serum ferritin and thyroid hormone profile in hypothyroidism. https://www.ijmsph.com/?mno=178386 [Access: April 05, 2022]. doi:10.5455/ijmsph.2015.24012015174

AMA (American Medical Association) Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. Association between serum ferritin and thyroid hormone profile in hypothyroidism. Int J Med Sci Public Health. 2015; 4(6): 863-865. doi:10.5455/ijmsph.2015.24012015174

Vancouver/ICMJE Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. Association between serum ferritin and thyroid hormone profile in hypothyroidism. Int J Med Sci Public Health. (2015), [cited April 05, 2022]; 4(6): 863-865. doi:10.5455/ijmsph.2015.24012015174

Harvard Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair (2015) Association between serum ferritin and thyroid hormone profile in hypothyroidism. Int J Med Sci Public Health, 4 (6), 863-865. doi:10.5455/ijmsph.2015.24012015174

Turabian Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. 2015. Association between serum ferritin and thyroid hormone profile in hypothyroidism. International Journal of Medical Science and Public Health, 4 (6), 863-865. doi:10.5455/ijmsph.2015.24012015174

Chicago Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. "Association between serum ferritin and thyroid hormone profile in hypothyroidism." International Journal of Medical Science and Public Health 4 (2015), 863-865. doi:10.5455/ijmsph.2015.24012015174

MLA (The Modern Language Association) Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair. "Association between serum ferritin and thyroid hormone profile in hypothyroidism." International Journal of Medical Science and Public Health 4.6 (2015), 863-865. Print. doi:10.5455/ijmsph.2015.24012015174

APA (American Psychological Association) Style

Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair (2015) Association between serum ferritin and thyroid hormone profile in hypothyroidism. International Journal of Medical Science and Public Health, 4 (6), 863-865. doi:10.5455/ijmsph.2015.24012015174

Authors retains the copyright of the manuscript/s published by them in this journal.

Copyright © 2023 International Journal of Medical Science and Public Health All Rights Reserved. Subject to change without notice from or liability to International Journal of Medical Science and Public Health. For best results, please use Internet Explorer or Google Chrome	Contact Information Publisher publisherijmsph@gmail.com Editorial query editorijmsph1@gmail.com MOB - 8780040272

Contact Information

How to cite this article