E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi.

Cited by (5)

Abstract
Background: Lymphocytes play an important role in wound healing and the removal of circulating T lymphocytes inhibits the healing cascade. Decreased stimulation of survival factors and increased levels of dead signals may lead to the malfunction of many cells, including lymphocytes.

Aims & Objective: To explore lymphocytes involvement in wound healing.

Material and Methods: Study participants were divided into three groups: group A, group B and group C (30 participants each). Annexin-V-FITC+CD-3-PE kit were used for the lymphocyte apoptosis estimation in diabetic foot patients by florescent activated cell sorter (FACS).

Results: We find out significantly higher total T cell apoptosis in type 2 diabetes mellitus patients having chronic, non healing diabetic foot ulcer as compared with healthy individuals. CD-3 + Annexin-V-FITC positive lymphocytes were statistically significant in group C (P<0.01) and group B (P<0.001) when compared from group A.

Conclusion: This study suggests the importance of T-lymphocytes in wound healing. From the present study we can suggest diabetic patients to maintain their immune system for the normal wound healing.

Key words: Diabetic foot, Apoptosis, Lymphocyte


 
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How to Cite this Article
Pubmed Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. 2013; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132


Web Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. https://www.ijmsph.com/?mno=34552 [Access: April 05, 2022]. doi:10.5455/ijmsph.2013.100620132


AMA (American Medical Association) Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. 2013; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132



Vancouver/ICMJE Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health. (2013), [cited April 05, 2022]; 2(4): 811-813. doi:10.5455/ijmsph.2013.100620132



Harvard Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi (2013) Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. Int J Med Sci Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132



Turabian Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. 2013. Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. International Journal of Medical Science and Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132



Chicago Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. "Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer." International Journal of Medical Science and Public Health 2 (2013), 811-813. doi:10.5455/ijmsph.2013.100620132



MLA (The Modern Language Association) Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi. "Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer." International Journal of Medical Science and Public Health 2.4 (2013), 811-813. Print. doi:10.5455/ijmsph.2013.100620132



APA (American Psychological Association) Style

Awadhesh Kumar Arya, Sunny Garg, Santosh Kumar, Lalit P Meena, Kamlakar Tripathi (2013) Estimation of lymphocyte apoptosis in patients with chronic, non healing diabetic foot ulcer. International Journal of Medical Science and Public Health, 2 (4), 811-813. doi:10.5455/ijmsph.2013.100620132





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