E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Association of TNF – α and uric acid in women with pre-eclampsia

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal.

Abstract
Background: TNF – α, a cytokine of a generalized intravascular inflammatory reaction, has been also shown to cause microvascular protein leakage and hypertrygliceridemia which are associated with pre-eclampsia. Increased serum uric acid is also associated with hypertension.

Aims & Objective: To study the relationship between Tumour Necrosis Factor – alpha (TNF – α) with uric acid and to access the role of TNF – α as a determinant of Pre-eclampsia in women.

Material and Methods: 100 patients with pre-eclampsia were studied out of which 50 were mild and 50 were severe pre-eclamptics. They were compared with 50 healthy subjects. Subjects were of similar gestational age, body mass index (BMI) and parity matched. They were all primigravidas at third trimester of pregnancy.

Results: All studied subjects belonged to age group 28-40 years. The difference in mean age of healthy subjects and pre-eclamptics was non-significant (P=0.8). BMI values were ranged from 18-43 kg/m2. No significant difference was observed between healthy pregnant women and pre-eclamptics. Serum TNF – α co-related significantly with Mean Arterial Pressure (MAP) and Uric acid levels. The association of TNF – α with uric acid was considerably significant compared to its association with other variables. The result showed that TNF – α is a strong determinant of preeclampsia.

Conclusion: A co-relation exists between TNF – α and uric acid. The observed co-relation indicates that monitoring TNF – α and uric acid levels in Pre-eclamptic women might serve to help prevent the development of pre-eclampsia in pregnant women.

Key words: Pre-eclampsia, TNF – α, Mean arterial pressure.


 
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REFERENCES
1. Davison JM, Homuth V, Jeyabalan A, Conrad KP, Karumanchi SA, Quaggin S, et al. New aspects in the pathophysiology of pre-eclampsia. J Am Soc Nephrol. 2004;15(9):2440-8. [DOI via Crossref]   
2. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183(1):S1-S22. [DOI via Crossref]   
3. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Pre-eclampsia: gestational trophoblastic disease. Harrison's principles of internal medicine. 18th edi. The McGraw-Hill Companies 2008. p. 815.
4. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet. 2002;77(1):67-75. [DOI via Crossref]   
5. Abulafia O, Sherer DM. Angiogenesis of the ovary. Am J Obstet Gynecol. 2000;182:240–246. [DOI via Crossref]   
6. Moffett A, Hiby SE. How Does the maternal immune system contribute to the development of pre-eclampsia? Placenta 2007;28 Suppl A:S51-6.
7. Nisell H, Lintu H, Lunell NO, Mollerstrom G, Pettersson E. Blood pressure and renal function seven years after pregnancy complicated by hypertension. Br J Obstet Gynaecol. 1995;102(11):876-81. [DOI via Crossref]   
8. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev. 1990;70(2):427-51.
9. Anderson JA, Miller FN, Sims DE, Edwards MJ. Tumor necrosis factor causes microvascular protein leakage independently of neutrophils or mast cells. J Surg Res. 1994;56(6):485-90. [DOI via Crossref]   
10. Bargale A, Sagare AA, Ganu JV, Trivedi DJ, Kamble PS. Effect of traditional Biochemical markers on endothelial dysfunction in preeclampsia. International Journal of Pharma and Biosciences 2012;3(3):B16-21.
11. Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med. 1992;175:323–9. [DOI via Crossref]   
12. Trinder P. A new method for the determination of plasma phenylalanine. Ann Clin Biochem. 1980;17(1):26-30. [DOI via Crossref]   
13. Catarino C, Santos SA, Belo L, Rocha PP, Rocha S, Patrício B, et al. Inflammatory disturbances in preeclampsia: relationship between maternal and umbilical cord blood. J Preg. 2012;1-10.

How to Cite this Article
Pubmed Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. Association of TNF – α and uric acid in women with pre-eclampsia. Int J Med Sci Public Health. 2013; 2(4): 1032-1036. doi:10.5455/ijmsph.2013.220820131


Web Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. Association of TNF – α and uric acid in women with pre-eclampsia. https://www.ijmsph.com/?mno=35802 [Access: April 05, 2022]. doi:10.5455/ijmsph.2013.220820131


AMA (American Medical Association) Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. Association of TNF – α and uric acid in women with pre-eclampsia. Int J Med Sci Public Health. 2013; 2(4): 1032-1036. doi:10.5455/ijmsph.2013.220820131



Vancouver/ICMJE Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. Association of TNF – α and uric acid in women with pre-eclampsia. Int J Med Sci Public Health. (2013), [cited April 05, 2022]; 2(4): 1032-1036. doi:10.5455/ijmsph.2013.220820131



Harvard Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal (2013) Association of TNF – α and uric acid in women with pre-eclampsia. Int J Med Sci Public Health, 2 (4), 1032-1036. doi:10.5455/ijmsph.2013.220820131



Turabian Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. 2013. Association of TNF – α and uric acid in women with pre-eclampsia. International Journal of Medical Science and Public Health, 2 (4), 1032-1036. doi:10.5455/ijmsph.2013.220820131



Chicago Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. "Association of TNF – α and uric acid in women with pre-eclampsia." International Journal of Medical Science and Public Health 2 (2013), 1032-1036. doi:10.5455/ijmsph.2013.220820131



MLA (The Modern Language Association) Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal. "Association of TNF – α and uric acid in women with pre-eclampsia." International Journal of Medical Science and Public Health 2.4 (2013), 1032-1036. Print. doi:10.5455/ijmsph.2013.220820131



APA (American Psychological Association) Style

Prerna Mittal, Anupam Bansal, Suresh Goyal, Kirti Kamal Jain, Alok Goyal (2013) Association of TNF – α and uric acid in women with pre-eclampsia. International Journal of Medical Science and Public Health, 2 (4), 1032-1036. doi:10.5455/ijmsph.2013.220820131





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