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Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan.

Cited by (1)

Abstract
Background: The impact of diagnostic immunohistochemistry for the surgical pathology is legendary especially when it provides true identity of undifferentiated tumours. This not only is important for prognostication & therapy but also provide further insights into the pathobiology of these tumours.

Aims & Objective: This study was undertaken to determine the role and significance of immunohistochemistry for accurate diagnosis and subtyping of undifferentiated malignant tumours as it is essential in guiding therapy and prognosis.

Material and Methods: Immunohistochemical staining (IHC) performed was based on Peroxidase Antiperoxidase (PAP) method on paraffin sections, using appropriate mono/polyclonal antibodies. Total 74 cases including six consultation cases were studied from August 2008 to November 2011, which were reported as undifferentiated or poorly differentiated malignant tumor using routine hematoxylin- eosin stains.

Results: The histopathology and IHC reports of 74 tumours were reviewed and assigned to appropriate categories. It was possible to arrive at a diagnosis in 73 cases (98.65%) with the help of IHC. Carcinoma was the commonest diagnosis (27 cases, 36.50%) followed by lymphoma (18 cases, 24.32%), sarcoma (14 cases, 18.92%), malignant melanoma (3 cases, 4.05%) and neuroblastoma (3 cases, 4.05%).

Conclusion: Immunohistochemistry is helpful in the majority of difficulties arising during histological diagnosis of undifferentiated malignant tumours and serves as a diagnostic, prognostic, and predictive tool.

Key words: Immunohistochemistry; Undifferentiated Malignant Tumour; Peroxidase Anti-Peroxidase Method; Differential Diagnosis


 
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This Article Cited By the following articles

IMMUNO HISTOCHEMICAL APPROACH TO THE DIAGNOSIS OF UNDIFFERENTIATED TUMOURS- AN INSTITUTIONAL STUDY
jebmh 2018; 5(21): 1647.

1
 
How to Cite this Article
Pubmed Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. Int J Med Sci Public Health. 2013; 2(4): 920-926. doi:10.5455/ijmsph.2013.110720133


Web Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. https://www.ijmsph.com/?mno=40364 [Access: April 05, 2022]. doi:10.5455/ijmsph.2013.110720133


AMA (American Medical Association) Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. Int J Med Sci Public Health. 2013; 2(4): 920-926. doi:10.5455/ijmsph.2013.110720133



Vancouver/ICMJE Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. Int J Med Sci Public Health. (2013), [cited April 05, 2022]; 2(4): 920-926. doi:10.5455/ijmsph.2013.110720133



Harvard Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan (2013) Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. Int J Med Sci Public Health, 2 (4), 920-926. doi:10.5455/ijmsph.2013.110720133



Turabian Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. 2013. Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. International Journal of Medical Science and Public Health, 2 (4), 920-926. doi:10.5455/ijmsph.2013.110720133



Chicago Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. "Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours." International Journal of Medical Science and Public Health 2 (2013), 920-926. doi:10.5455/ijmsph.2013.110720133



MLA (The Modern Language Association) Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan. "Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours." International Journal of Medical Science and Public Health 2.4 (2013), 920-926. Print. doi:10.5455/ijmsph.2013.110720133



APA (American Psychological Association) Style

Vasudha Mahendra Bhagat, Amita Ramesh bhai Patel, Jigna Pravin chandra Modi, Peeyush Kumar Saini, Hemali Jayantilal Tailor, Kumarbhargav Ramesh chandra Kaptan (2013) Immunohistochemistry: A diagnostic tool for accurate characterization of undifferentiated malignant tumours. International Journal of Medical Science and Public Health, 2 (4), 920-926. doi:10.5455/ijmsph.2013.110720133





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