Association between body mass index, lipid peroxidation and coronary lipid  risk factors in hypothyroid subjects

V Shanmugapriya; PK Mohanty; D Anil Kumar

doi:10.5455/ijmsph.2013.010920132

2021, Vol: 10, Issue: 2

10 / 2Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Research

Int J Med Sci Public Health. 2013; 2(4): 1063-1067

doi: 10.5455/ijmsph.2013.010920132

Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects

V Shanmugapriya, PK Mohanty, D Anil Kumar.

Cited by (1)

Abstract
Background: Thyroid hormones plays an important role in control of metabolism in human. Hyperlipidaemia particularly hypercholesterolemia, is a well-documented significant health consequence associated with hypo-thyroidism. Oxidative stress is a common factor associated with several clinical conditions including hypothyroidism.

Aims & Objective: To evaluate the association between BMI, Hyperlipidaemia, Lipid Peroxidation and Atherogenic risk in newly diagnosed hypothyroid patients.

Material and Methods: 85 newly diagnosed hypothyroid cases and 41 euthyroid controls were studied for their Thyroid profile [TSH, T4 andT3], Lipid profile , Oxidative stress marker, Malondialdehyde {MDA} Lipid risk ratios, [TC/HDL-C and LDL-C / HDL-C ratio] , Atherogenic index [AIP] - log TG/HDL-C and Body Mass Index [BMI].

Results: Hypothyroid patients had hyperlipidaemia, especially hypercholesterolemia [224 Â± 43.8 mg/dl], increased LDL-C level [150.4 Â± 42.3 mg/dl] when compared to controls [169.5 Â± 25.1 and 97 Â± 25.5 respectively]. MDA was significantly increased [p< 0.0001] in hypothyroid subjects [6.14Â± 1.83Î¼ mol/L] versus the controls [2.9 Â± 0.86 Î¼mol/L] .BMI had positive correlation with TSH [r =4.421; p<0.0001].

Conclusion: Hypothyroidism leads to hyperlipidaemia enhancing risk for cardiovascular diseases, the connecting link being oxidative stress. It was found that TSH had positive significant correlation with BMI, Lipid profile and oxidative stress in hypothyroid patients when compared to the controls making them more prone for coronary artery diseases.

Key words: Hypothyroidism; Body Mass Index (BMI); Thyroid Stimulating Hormone (TSH); Atherogenic Index

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by V Shanmugapriya Articles by PK Mohanty Articles by D Anil Kumar
	on Google
	on Google Scholar

REFERENCES

1. Kochupillai N. Clinical endocrinology in India. Curr Sci. 2000;79:1061Ã¢Â€Â“7.

2. Nanda N, Bobby Z, Hamide A. Association of thyropid stimulating hormone and coronary lipid risk factors with lipid peroxidation in hypothyroidism. Clin Chem Lab Med 2008;46(5):674-9. [DOI via Crossref]

3. Guyton AC. The Thyroid metabolic hormones. In: Guyton AC, Hall JE. eds. Textbook of Medical Physiology 8th edi. Philadelphia, Pa: WB Saunders Company. 2000. p. 831-41.

4. Caraccio N, Natali A, Sironi A, Baldi S, Frascerra S, Dardano A, et al. Muscle metabolism and exercise tolerance in subclinical hypothyroidism: A controlled trial of levothyroxine . J Clin Endocrinol Metab 2005;90(7):4057-62. [DOI via Crossref]

5. Gullu S, Sav H, Kamel N. Effect of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. Eur J Endocrinol 2005;152(3):355-61. [DOI via Crossref]

6. Coria MJ, PastrÃƒÂ¡n AI, Gimenez MS. Serum oxidative stress parameters of women with hypothyroidism. Acta Biomed 2009;80(2):135-9.

7. Del Rio D, Stewart AJ, pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15(4):316-28. [DOI via Crossref]

8. Esterbauer H. Cytotoxicity and genotoxicity of lipid-oxidation products Am J Clin Nutr 1993. 57779SÃ¢Â€Â“785S.785Sdiscussion 785SÃ¢Â€Â“786S.

9. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.

10. Onat A, Can G, Kaya H, HergenÃƒÂ§ G. Atherogenic index of plasma" (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol. 2010;4(2):89-98. [DOI via Crossref]

11. Arumalla VK, Vani N, Ramarao J. Dose- dependent Impacts on the Diagnostic Efficacies of Atherogenic Lipids in Adult Indian Smokers. Journal of Clinical and Diagnostic Research 2011;5(7):1352 Ã¢Â€Â“ 5.

12. Nwagha UI, Ikekpeazu EJ, Ejezie FE, Neboh EE, Maduka IC. Atherogenic index of plasma as useful predictor of cardiovascular risk among postmenopausal women in Enugu, Nigeria. Afr Health Sci. 2010;10(3):248-52.

This Article Cited By the following articles

Anti-hyperglycaemic effects of herbal porridge made of Scoparia dulcis leaf extract in diabetics Ã¢Â€Â“ a randomized crossover clinical trial BMC Complement Altern Med 2015; 15(1): .	1

How to Cite this Article

Pubmed Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. 2013; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132

Web Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. https://www.ijmsph.com/?mno=47027 [Access: April 05, 2022]. doi:10.5455/ijmsph.2013.010920132

AMA (American Medical Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. 2013; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132

Vancouver/ICMJE Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. (2013), [cited April 05, 2022]; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132

Harvard Style

V Shanmugapriya, PK Mohanty, D Anil Kumar (2013) Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132

Turabian Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. 2013. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. International Journal of Medical Science and Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132

Chicago Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. "Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects." International Journal of Medical Science and Public Health 2 (2013), 1063-1067. doi:10.5455/ijmsph.2013.010920132

MLA (The Modern Language Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. "Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects." International Journal of Medical Science and Public Health 2.4 (2013), 1063-1067. Print. doi:10.5455/ijmsph.2013.010920132

APA (American Psychological Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar (2013) Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. International Journal of Medical Science and Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132

Authors retains the copyright of the manuscript/s published by them in this journal.

Copyright © 2022 International Journal of Medical Science and Public Health All Rights Reserved. Subject to change without notice from or liability to International Journal of Medical Science and Public Health. For best results, please use Internet Explorer or Google Chrome	Contact Information Publisher publisherijmsph@gmail.com Editorial query editorijmsph1@gmail.com MOB - 8780040272

Contact Information

How to cite this article