E-ISSN 2277-338X | ISSN 2320-4664
 

Original Research 


Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects

V Shanmugapriya, PK Mohanty, D Anil Kumar.

Cited by (1)

Abstract
Background: Thyroid hormones plays an important role in control of metabolism in human. Hyperlipidaemia particularly hypercholesterolemia, is a well-documented significant health consequence associated with hypo-thyroidism. Oxidative stress is a common factor associated with several clinical conditions including hypothyroidism.

Aims & Objective: To evaluate the association between BMI, Hyperlipidaemia, Lipid Peroxidation and Atherogenic risk in newly diagnosed hypothyroid patients.

Material and Methods: 85 newly diagnosed hypothyroid cases and 41 euthyroid controls were studied for their Thyroid profile [TSH, T4 andT3], Lipid profile , Oxidative stress marker, Malondialdehyde {MDA} Lipid risk ratios, [TC/HDL-C and LDL-C / HDL-C ratio] , Atherogenic index [AIP] - log TG/HDL-C and Body Mass Index [BMI].

Results: Hypothyroid patients had hyperlipidaemia, especially hypercholesterolemia [224 ± 43.8 mg/dl], increased LDL-C level [150.4 ± 42.3 mg/dl] when compared to controls [169.5 ± 25.1 and 97 ± 25.5 respectively]. MDA was significantly increased [p< 0.0001] in hypothyroid subjects [6.14± 1.83μ mol/L] versus the controls [2.9 ± 0.86 μmol/L] .BMI had positive correlation with TSH [r =4.421; p<0.0001].

Conclusion: Hypothyroidism leads to hyperlipidaemia enhancing risk for cardiovascular diseases, the connecting link being oxidative stress. It was found that TSH had positive significant correlation with BMI, Lipid profile and oxidative stress in hypothyroid patients when compared to the controls making them more prone for coronary artery diseases.

Key words: Hypothyroidism; Body Mass Index (BMI); Thyroid Stimulating Hormone (TSH); Atherogenic Index


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by V Shanmugapriya
Articles by PK Mohanty
Articles by D Anil Kumar
on Google
on Google Scholar


REFERENCES
1. Kochupillai N. Clinical endocrinology in India. Curr Sci. 2000;79:1061–7.
2. Nanda N, Bobby Z, Hamide A. Association of thyropid stimulating hormone and coronary lipid risk factors with lipid peroxidation in hypothyroidism. Clin Chem Lab Med 2008;46(5):674-9. [DOI via Crossref]   
3. Guyton AC. The Thyroid metabolic hormones. In: Guyton AC, Hall JE. eds. Textbook of Medical Physiology 8th edi. Philadelphia, Pa: WB Saunders Company. 2000. p. 831-41.
4. Caraccio N, Natali A, Sironi A, Baldi S, Frascerra S, Dardano A, et al. Muscle metabolism and exercise tolerance in subclinical hypothyroidism: A controlled trial of levothyroxine . J Clin Endocrinol Metab 2005;90(7):4057-62. [DOI via Crossref]   
5. Gullu S, Sav H, Kamel N. Effect of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. Eur J Endocrinol 2005;152(3):355-61. [DOI via Crossref]   
6. Coria MJ, Pastrán AI, Gimenez MS. Serum oxidative stress parameters of women with hypothyroidism. Acta Biomed 2009;80(2):135-9.
7. Del Rio D, Stewart AJ, pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15(4):316-28. [DOI via Crossref]   
8. Esterbauer H. Cytotoxicity and genotoxicity of lipid-oxidation products Am J Clin Nutr 1993. 57779S–785S.785Sdiscussion 785S–786S.
9. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
10. Onat A, Can G, Kaya H, Hergenç G. Atherogenic index of plasma" (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol. 2010;4(2):89-98. [DOI via Crossref]   
11. Arumalla VK, Vani N, Ramarao J. Dose- dependent Impacts on the Diagnostic Efficacies of Atherogenic Lipids in Adult Indian Smokers. Journal of Clinical and Diagnostic Research 2011;5(7):1352 – 5.
12. Nwagha UI, Ikekpeazu EJ, Ejezie FE, Neboh EE, Maduka IC. Atherogenic index of plasma as useful predictor of cardiovascular risk among postmenopausal women in Enugu, Nigeria. Afr Health Sci. 2010;10(3):248-52.

This Article Cited By the following articles

Anti-hyperglycaemic effects of herbal porridge made of Scoparia dulcis leaf extract in diabetics – a randomized crossover clinical trial
BMC Complement Altern Med 2015; 15(1): .

1
 
How to Cite this Article
Pubmed Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. 2013; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132


Web Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. https://www.ijmsph.com/?mno=47027 [Access: April 05, 2022]. doi:10.5455/ijmsph.2013.010920132


AMA (American Medical Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. 2013; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132



Vancouver/ICMJE Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health. (2013), [cited April 05, 2022]; 2(4): 1063-1067. doi:10.5455/ijmsph.2013.010920132



Harvard Style

V Shanmugapriya, PK Mohanty, D Anil Kumar (2013) Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. Int J Med Sci Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132



Turabian Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. 2013. Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. International Journal of Medical Science and Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132



Chicago Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. "Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects." International Journal of Medical Science and Public Health 2 (2013), 1063-1067. doi:10.5455/ijmsph.2013.010920132



MLA (The Modern Language Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar. "Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects." International Journal of Medical Science and Public Health 2.4 (2013), 1063-1067. Print. doi:10.5455/ijmsph.2013.010920132



APA (American Psychological Association) Style

V Shanmugapriya, PK Mohanty, D Anil Kumar (2013) Association between body mass index, lipid peroxidation and coronary lipid risk factors in hypothyroid subjects. International Journal of Medical Science and Public Health, 2 (4), 1063-1067. doi:10.5455/ijmsph.2013.010920132





Most Viewed Articles
  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11

  • Diabetic nephropathy: Progression and pathophysiology
    Deepak N Parchwani, Amit A Upadhyah
    Int J Med Sci Public Health. 2012; 1(2): 59-70
    » Abstract & References » doi: 10.5455/ijmsph.2012.1.59-70

  • Elevated levels of serum uric acid, creatinine or urea in preeclamptic women
    Magna Manjareeka, Sitikantha Nanda
    Int J Med Sci Public Health. 2013; 2(1): 43-47
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.43-47

  • Most Downloaded
  • Minor disorder of pregnancy and its home management
    Lata Gururani, Atul Kumar, Gomathi Mahalingam
    Int J Med Sci Public Health. 2016; 5(4): 684-687
    » Abstract & References » doi: 10.5455/ijmsph.2016.03082015111

  • Association between serum ferritin and thyroid hormone profile in hypothyroidism
    Ashuma Sachdeva, Veena Singh, Isha Malik, Prasanta Saha Roy, Himanshu Madaan, Rajesh Nair
    Int J Med Sci Public Health. 2015; 4(6): 863-865
    » Abstract & References » doi: 10.5455/ijmsph.2015.24012015174

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142

  • Effect of sleep deprivation on the attitude and performance of medical students, Riyadh, Saudi Arabia
    Hussein Saad Amin, Ibrahim Salamah Almazroua, Abdullah Sulaiman Alsahlan, Mohammed Abdullah Alrishan, Houssam Mourad Elmourad, Mohammed Mansour Alotaibi, Abdulaziz Ibrahim Almohaisin
    Int J Med Sci Public Health. 2016; 5(3): 575-580
    » Abstract & References » doi: 10.5455/ijmsph.2016.17112015207

  • Management of Appendicular Lump: Early exploration Vs conservative management
    Chandra Prakash Pandey, Ram Chandra Kesharwani, Chandra Gopal Singh Chauhan, Manmohan Krishna Pandey, Purnima Mittra, Pramod Kumar, Arshad Raza
    Int J Med Sci Public Health. 2013; 2(4): 1046-1049
    » Abstract & References » doi: 10.5455/ijmsph.2013.230820131

  • Most Cited Articles
  • Zinc: The trace element of major importance in human nutrition and health
    Jayant D Deshpande, Mohini M Joshi, Purushottam A Giri
    Int J Med Sci Public Health. 2013; 2(1): 1-6
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.1-6
    Cited : 61 times [Click to see citing articles]

  • Internet addiction among professional courses students: A study from central India
    Arvind Sharma, Rupesh Sahu, Pradeep Kumar Kasar, Richa Sharma
    Int J Med Sci Public Health. 2014; 3(9): 1069-1073
    » Abstract & References » doi: 10.5455/ijmsph.2014.180620142
    Cited : 26 times [Click to see citing articles]

  • A study on the prevalence of refractive errors among school childern of 7-15 years age group in the field practice areas of a medical college in bangalore
    Pavithra MB, Maheshwaran R, Rani Sujatha MA
    Int J Med Sci Public Health. 2013; 2(3): 641-645
    » Abstract & References » doi: 10.5455/ijmsph.2013.220420131
    Cited : 23 times [Click to see citing articles]

  • Examination stress and its effect on EEG
    Sunil Kumar Jena
    Int J Med Sci Public Health. 2015; 4(11): 1493-1497
    » Abstract & References » doi: 10.5455/ijmsph.2015.23042015308
    Cited : 23 times [Click to see citing articles]

  • Burden of non communicable diseases in India: Setting priority for action
    Kalpa Sharma
    Int J Med Sci Public Health. 2013; 2(1): 7-11
    » Abstract & References » doi: 10.5455/ijmsph.2013.2.7-11
    Cited : 21 times [Click to see citing articles]